Protein Alignment SLC22A and SVOP

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_061181.1
• Gene: SVOP / 55530
• HGNCID: 25417
• Length: 548
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 138/575 - (24%)
• Similarity: 219/575 - (38%)
• Gaps: 176/575 - (30%)

  Fly    14 EVAPPAKDS---EDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSV 75
            |.|.|..|:   || .::||     .||:||..:.:|..|..|..||..:.....|..:
Human    59 EFANPTDDTFMVED-AVEAI-----GFGKFQWKLSVLTGLAWMADAMEMMILSILAPQL------ 111

  Fly    76 EECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFV 140
                         |..|.:|
Human   112 -------------HCEWRLP--------------------------------------------- 118

  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205
                              .|:::::.::..:|......:.|.::|:|||...:.:..:.....|:
Human   119 ------------------SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGI 165

  Fly   206 IRSFSPSYGWFLVFEFLDNM------TSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVG--- 261
            :.:|:|.|.|.||...|...      .|.|||:       |.:..|.|.....:|.||:|:|
Human   166 LSAFAPVYSWILVLRGLVGFGIGGVPQSVTLYA-------EFLPMKARAKCILLIEVFWAIGTVF 223

  Fly   262 EVLLAMSAKAFHDWRILLRITYGPSLILLAY--FWILPESVRWLLSQGKEERAKNILRRAAHVNK 324
            ||:||:.......||.||.::..| |:|.|.  || ||||.|:.:..|.:|:|...|:|.|..|.
Human   224 EVVLAVFVMPSLGWRWLLILSAVP-LLLFAVLCFW-LPESARYDVLSGNQEKAIATLKRIATENG 286

  Fly   325 RELPESVLDKLVLANRDKLQQSSESRFPIREAF-KNFKWRIANCSLCWIVHVLVYYGL------- 381
            ..:|   |.||:::.:       |.|..:|:.| .:|:|........|..:...||||
Human   287 APMP---LGKLIISRQ-------EDRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTEL 341

  Fly   382 --------------------SLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRR------ 420
                                ||....|..:.|.:..:..|.|.||..:.|.|:||.||:
Human   342 FQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALC 406

  Fly   421 ---YSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSL 482
               :|.|.|:|   ..|:|       :.||.|:|| :.:..|:..||..|.:..|:|||..|...
Human   407 FVIFSFCSLLL---FICVG-------RNVLTLLLF-IARAFISGGFQAAYVYTPEVYPTATRALG 460

  Fly   483 LSFCSMMGRFGSMLAPQTPLLAKYYANAPAML----FAGAAIVSGLLTLFFPETT 533
            |..||.|.|.|:::   ||.:|:....:...|    ::|..:::.|.:.|.|..|
Human   461 LGTCSGMARVGALI---TPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIET 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	130/551 (24%)
		MFS	146..530	CDD:119392	115/435 (26%)
SVOP	NP_061181.1	MFS_SVOP	87..509	CDD:340999	124/536 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.666667	Normalized mean entropy	S2472
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860