Protein Alignment SLC22A and SLC22A17

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_065105.3
• Gene: SLC22A17 / 51310
• HGNCID: 23095
• Length: 649
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 141/619 - (22%)
• Similarity: 240/619 - (38%)
• Gaps: 162/619 - (26%)

  Fly    17 PPAKDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAM-FSVTYVFTAATVTHRCSVEECDL 80
            ||.    .::.:|:|..:|..|..|.:...|.|||::|.|: .:...:||.|...|      |
Human    74 PPG----PLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGMASDPIFTLAPPLH------C-- 126

  Fly    81 PGSNY--YEPH-TNWSIPKNGKDLD--------------------SCNRYTNSELPQWNHSVDIC 122
               :|  :.|: :.|..|.|...:.                    ||:.:..   |.:||    |
Human   127 ---HYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAP---PDFNH----C 181

  Fly   123 SADHFTKNKEACAHNEFVFRDDEVTISNDFG---IFCDDEWKLSMVGTINNLGQFFGIPIGGFVA 184
            ..|             :.:....|..:|..|   :.||..|::.:...:..||...|....|:.|
Human   182 LKD-------------WDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPA 233

  Fly   185 DRYGRSFSIALG-GILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRV 248
            ||:||...:.|. |::|. .||..:.:.|....:...||.....:.:....:::.:||..|.:|:
Human   234 DRFGRRGIVLLTLGLVGP-CGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRL 297

  Fly   249 ---LACSVITV---FYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFW--ILPESVRWLLS 305
               ||..::.|   |..:|   ||:.:|   |||.|.|:...|.::.|.|.|  :..||.|||:.
Human   298 RVALAGELVGVGGHFLFLG---LALVSK---DWRFLQRMITAPCILFLFYGWPGLFLESARWLIV 356

  Fly   306 QGKEERAKNILRRAAHVNK-------RELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWR 363
            :.:.|.|:::||..|..|:       .|..|::.|   |.|...|..:|...|.....::|. |:
Human   357 KRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQD---LENTCPLPATSSFSFASLLNYRNI-WK 417

  Fly   364 IANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIAL----VEIPG------FFMPLLI----- 413
                                |:::|.   :.||...|:    ..:.|      |::..|:
Human   418 --------------------NLLILG---FTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTA 459

  Fly   414 ----------MDRFGRRYSLCGLMLASGLCCIGTIFTG---ADQPVLQLVLFLVG-------KLT 458
                      :||||||..|...|..:|:..:  :..|   .:.|:...|....|       :..
Human   460 ALACVFLGVTVDRFGRRGILLLSMTLTGIASL--VLLGLWDCEHPIFPTVWAQQGNPNRDLNEAA 522

  Fly   459 ITASFQVLYFF------------ASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAP 511
            || :|.||..|            |:|:.||.:|...|.....:|..|.:..|...|...:.|...
Human   523 IT-TFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQ 586

  Fly   512 AMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEAD 545
            .::.|..|::..|..:..|||...:||..:::.:
Human   587 HVVLAACALLCILSIMLLPETKRKLLPEVLRDGE 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	137/594 (23%)
		MFS	146..530	CDD:119392	106/449 (24%)
SLC22A17	NP_065105.3	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010