DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and slc22a15.1

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_031751719.1	Gene:	slc22a15.1 / 448510	XenbaseID:	XB-GENE-959503	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	556	Identity:	151/556 - (27%)
Similarity:	245/556 - (44%)	Gaps:	65/556 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LDAILKHLGQFGRFQLII-FLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT 90
            ::..||.:|:.|.:|:.: |||..|..::.|..::......||                   |..
Frog    29 VEGALKLVGEMGIYQIYLSFLLAVLLQLYSATEAIIITILGAT-------------------PPY 74

  Fly    91 NW---SIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISNDF 152
            :|   |:..||    |..:...|:||....                  |...||..:..:|.:::
Frog    75 HWMNDSLTANG----SRGKQYGSQLPAEGE------------------HGHVVFDGNFTSIVSEW 117

  Fly   153 GIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFL 217
            .:.....:::|:..::...|...|:...|.::||:||......|..|..|..|:.:.:|.:..||
Frog   118 FLVGGAAYEVSVSSSVYFGGVLIGVISFGQLSDRFGRKPVYVTGLALEVVFAVMNALTPIFPLFL 182

  Fly   218 VFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRIT 282
            :..||..:.:..:....||:..|.:|......|.|:.::.:|||....|:.......||:|..:.
Frog   183 LTRFLVGVMNGGMSLVAFVLLNECIGASYWAAAGSLGSLCFAVGIAQFALIGYFIRSWRLLALLV 247

  Fly   283 YGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQSS 347
            ......:||....:|||.|||.:||:...|:..|......|:|:     :....|..|   |:.|
Frog   248 NVQGAAVLALSLCIPESPRWLHAQGRLREAQESLLSLGRRNRRK-----VTSFTLCPR---QKDS 304

  Fly   348 ESRFPIREAFKNFKWRIANCSLCWIVHV--LVYYGLSLNVVLLDGDKYNNFAYIALVEIPGF--F 408
            .....|...:.|...|.....:.|:..|  ||||||:|:...|.||.|.|.|...|.|:|.:  .
Frog   305 AHSANILTIYSNAILRQRTLIMMWVWFVCSLVYYGLTLSSGDLGGDIYLNLALSGLAELPAYPLC 369

  Fly   409 MPLLIMDRFGRRYSLCGLMLASGLCCI------GTIFTGADQPVLQLVLFLVGKLTITASFQVLY 467
            |.|:...|.|||.||.|.:...|..|:      |...:|....:....|.|:|||.|:|:|.::|
Frog   370 MYLINHKRVGRRGSLAGFLCVGGGACLLIMLVPGKTGSGPLSVLNSQTLSLLGKLNISAAFNIVY 434

  Fly   468 FFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPET 532
            .::||:|||.:||..:..|||..|.|.::||..|.|...:...|.::|..|.:.:|||:|..|||
Frog   435 IYSSELYPTCVRNLGMGVCSMFSRIGGIIAPFIPALRFAHWALPFIVFGAAGVSAGLLSLLLPET 499

  Fly   533 TNVVLPTTVQEADAIGVKKQSKSKDLDLVVTATQAQ 568
            .:..||.|:  ||..|...:....|.:.::...||:
Frog   500 LSAPLPETL--ADLRGAPYRRLEPDGEAMLHRPQAE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	142/518 (27%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	115/393 (29%)
slc22a15.1	XP_031751719.1	MFS	90..497	CDD:421695	121/432 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930