Protein Alignment SLC22A and Slc22a28

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001013842.2
• Gene: Slc22a28 / 434674
• MGIID: 3645714
• Length: 552
• Species: Mus musculus
• Alignment Length: 576
• Identity: 143/576 - (24%)
• Similarity: 255/576 - (44%)
• Gaps: 69/576 - (11%)

  Fly    30 ILKHLGQFGRFQL--IIFLLICLPMMFHAMFSVTYV----FTAATVTHRC--SVEECDLPGSN-- 84
            :|..:|..||||:  |.|:|..:.::      |.::    ||||...|||  .:.:.|....|
Mouse     6 LLNQVGSLGRFQILQISFVLFLVGLV------VPHITMENFTAAIPNHRCWAPILDNDTASDNGS 64

  Fly    85 ---YYEPHTNWSIPKNGK-DLDSCNRYTNSELPQWNHSVDI--CSADHFTKNKEACAHNEFVFRD 143
               ..:.....|||.:.. .||.|.|:..   ||| |.:.:  ..::....:.|.|.......|.
Mouse    65 RILSQDDLLRISIPLDSNLRLDKCRRFAQ---PQW-HLLHLNGTFSNETEPDTEPCVDGWVYDRS 125

  Fly   144 DEV-TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIR 207
            :.: ||..::.:.|:.:...|:......:|.|.|..|.|.::||:||.|.:....:..|:.....
Mouse   126 NFLSTIVTEWDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGRKFILTCALLQFAITETCV 190

  Fly   208 SFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAF 272
            :|:||:..:.:..||..|:...:.....::.:|...||...:...:.:...::|.::||..|..|
Mouse   191 AFAPSFFIYCLLRFLAGMSVEPISVNSNLLILEWTNPKFLGMVAVLTSCAASIGYMILAGLAFLF 255

  Fly   273 HDWRILLRITYGPSLILLAYFWIL----PESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLD 333
            ..|..|......|    :.:|:||    .||.|||:...|.::....||:.||:|..:...:.|.
Mouse   256 RIWHHLQLAMSVP----IFFFFILTRWMSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGNTLT 316

  Fly   334 KLVL--ANRDKLQQSSESRFPIREAFKN--FKWRIANCSLCWIVHVLVYYGLSL-------NVVL 387
            ..|:  :.:::|:.:.....| |:.|..  .:.||...|....:..:..:||||       |::|
Mouse   317 MEVVEASMKNELEAAKRKSSP-RDLFHTPILRNRICVLSFMRYLFTVSIFGLSLHLQHLSTNIIL 380

  Fly   388 LDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLF 452
            |   ::.:.|...|:.:.|.|    :::..|||.:...||...|:..:..:|...:...|::::
Mouse   381 L---RFLSSALGILISVIGHF----VLNHMGRRITQLVLMSLRGIFMLTAVFVPQEMQTLRIIV- 437

  Fly   453 LVGKLTITASFQVLYFFAS-----EIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPA 512
                :|:.|:...|....|     |:.||.||.:.:....|.|..|..|||...|||.|.||.|.
Mouse   438 ----VTLAAALSSLCMCVSNLHINELLPTTLRATGMGVIGMFGNSGLFLAPLFMLLATYSANLPW 498

  Fly   513 MLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIG--VKKQSKSKDLDLVVTATQ 566
            :.:.|.:|:.|......|||.|..||.::.:   :|  .|...::|:.|.::..|:
Mouse   499 IFYGGFSILYGFSVFLLPETKNQPLPDSIHD---VGNDWKDSRQAKEEDSIIKVTR 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	137/541 (25%)
		MFS	146..530	CDD:119392	99/404 (25%)
Slc22a28	NP_001013842.2	2A0119	11..525	CDD:273328	136/540 (25%)
		MFS	151..516	CDD:119392	95/381 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940