DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CG16727

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	136/543 - (25%)
Similarity:	247/543 - (45%)	Gaps:	45/543 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYE---PH 89
            |.:|:..|.|||||.:|.:|.....:..::...:......|..|.||.:  ||.|....|   .:
  Fly     4 DRVLEKCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTPEHWCSHD--DLMGLGAAELRSIY 66

  Fly    90 TNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDE--VTISNDF 152
            :|.|.|       ||     :.|.:..:...:.|       :|:|  .:::|..:.  .:::.:.
  Fly    67 SNVSHP-------SC-----TLLSEVINGTGVAS-------EESC--QDWIFERENGYESLTTEL 110

  Fly   153 GIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFL 217
            ...||...:.::..:...||...|....||::|..||..::.:..:.||....|.||..:..||.
  Fly   111 KWVCDKSHQPAVGQSFFFLGSVVGTISFGFLSDHIGRLPAMLMAALSGATGDFITSFVHTLPWFA 175

  Fly   218 VFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVI-TVFYAVGEVLLAMSAKAFHDWRILLRI 281
            ...|:..:::.|:|...:::..|.:.||||....::| .|||..|.:.....|....:||..|.:
  Fly   176 FSRFVSGLSTDTMYYLMYILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRYLWL 240

  Fly   282 TYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQS 346
            ...|:|.:|.|..::.||.:|||::.|.:.|...|::.|..|.|::.:||.|:.|...|:|:.:.
  Fly   241 ASLPALGVLIYPLLICESAQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEFVKHYREKMNEE 305

  Fly   347 SESRFPIRE---AFKNFKWRIANCSLC--WIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPG 406
            |:....:..   .||..:.|....:|.  .::..|.|..::.|:..|....:..|:..:.|.:|.
  Fly   306 SKLNKQMDTFLGMFKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSPFKLFSLTSSVYLPA 370

  Fly   407 FFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTG--------ADQPVLQLVLFLVGKLTITASF 463
            .|..||:.::.||:...||.:|...:.   |..||        ::..||..::..:|:...|.|:
  Fly   371 GFTILLLQNKIGRKGMACGALLVGAII---TAVTGFLIAVLDPSENAVLLALMVGLGRFGTTVSY 432

  Fly   464 QVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLF 528
            .....:|:||.||::|...:|...::|...|.||.....||:||...|::..:....:..||.|.
  Fly   433 DAEIQYAAEIIPTSVRGQAVSNIHVVGLASSSLAFYVIYLAQYYKPLPSIFISVLMFLGALLCLT 497

  Fly   529 FPETTNVVLPTTVQEADAIGVKK 551
            .|||.:..||.|:.:.:...:.:
  Fly   498 LPETLHKKLPETLADGERFAMNE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	133/523 (25%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	102/397 (26%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	133/523 (25%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	100/376 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458504
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990