DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CG17752

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_650817.1	Gene:	CG17752 / 42337	FlyBaseID:	FBgn0038718	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	142/572 - (24%)
Similarity:	245/572 - (42%)	Gaps:	82/572 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCS--VEECDLPGSNYYEPH 89
            |..:|:..|.||.:|:::..|.....:..::...:....:.|.:||||  |||
  Fly     3 LQRVLEKCGNFGPYQILLLGLYGYTNIVSSLHYFSQTLISFTPSHRCSAPVEE------------ 55

  Fly    90 TNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISNDFGI 154
                ..:|..:|.||:..        .:.||:.|   |..||  |:..:|....:..:|:.:...
  Fly    56 ----FSQNFTELLSCSVI--------QYDVDMTS---FRDNK--CSSWDFDKESNYESITTELEW 103

  Fly   155 FCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVF 219
            .|||.:||::..:...:|...|....|::|||.||..:..|..:.||......||..|...|...
  Fly   104 VCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPMFSFT 168

  Fly   220 EFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVIT-VFYAVGEVLLAMSAKAFHDWRILLRITY 283
            .|:..::..|.|...:::..|.:.|:.|....::|. |||::|.::....|....:||..|....
  Fly   169 RFISGLSMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYSIGLMISPWIAIWLGNWRSYLWAAS 233

  Fly   284 GPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKL----Q 344
            .|:|.:|.:...|.|||.|||::||.::|.|.|:..|..|.|::.:||.|:.:...|:||    :
  Fly   234 LPALGMLIFPLFLHESVEWLLTKGKFDKAVNNLKSVAKFNGRQVEDSVFDEFIKHYREKLNSAQK 298

  Fly   345 QSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFM 409
            :||::...:....:..|:.|.......|: .:.:..||.||..:....:..|:|...|.:||...
  Fly   299 KSSDTFMGMLRTPRLRKFTIILLIKSMII-TIAFDILSRNVEGVGISPFKLFSYSGFVVLPGGLS 362

  Fly   410 PLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFF----- 469
            .:|..::.||:...|..:|.....   |..||          :|||.|. .|::.||..|
  Fly   363 IILFQNKIGRKGMACASLLVGAFI---TATTG----------YLVGTLD-PANYSVLLGFMVCLA 413

  Fly   470 --------------ASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAI 520
                          |:||.||::|...::...::|...:..:.....|..:|...|::|.:...|
  Fly   414 RFGAVVAYDAEAQYAAEIIPTSVRGRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLLISFLLI 478

  Fly   521 VSGLLTLFFPETTNVVLPTTVQEAD------------AIGVKKQSKSKDLDL 560
            :...|.|..|||.:..||.|::|.:            ....|:||...:..|
  Fly   479 IGACLCLTLPETLHKQLPQTLEEGEIFAKGEKWYFFPCFSRKRQSNKSESQL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	134/530 (25%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	104/407 (26%)
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	134/530 (25%)
CG17752	NP_650817.1	MFS	116..488	CDD:119392	98/386 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458506
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990