DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CG6126

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	170/542 - (31%)
Similarity:	263/542 - (48%)	Gaps:	43/542 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEP 88
            |..|:.::..||:||::|.:.|.|..|..:...|..::.|..||...|||.:|..|    |....
  Fly     4 DYVLEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVD----NSSLS 64

  Fly    89 HTNW-------SIP-KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDE 145
            .|.|       :|| |...:|:||..:..|. |..|.::          |.|...::...::...
  Fly    65 VTPWNSSAILAAIPLKPNGELESCLMFDPSS-PGTNTTI----------NCERYVYDTTYYKTSR 118

  Fly   146 VTISNDFGIFCDDEWKLSMVGTINNLGQFFG-IPIGGFVADRYGRSFSIALGGILGAVLGVIRSF 209
             ||  |:...||..|..::|.|:..||.|.| :.:|| :||:.||........:...::||..:|
  Fly   119 -TI--DWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGG-LADKVGRKTVFCWSALFQLIIGVGVAF 179

  Fly   210 SPSYGWFLVFEFLDNMTSST-LYSTCFVIGIELVGPKRRVLACSVITVFYAV--GEVLLAMSAKA 271
            .|.|..|:|..:|..:..|. .|...||:.:|||||.:|.: |.:  .|.||  |.::|.....|
  Fly   180 IPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTV-CGI--TFQAVFAGGIMLVAGWGA 241

  Fly   272 FHDWRILLRITYG-PSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKL 335
            ....|..|::.|| ...:.|.::|.|.||.|||..||:...|.:|:.:...:|...:|   :||.
  Fly   242 LIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIP---VDKE 303

  Fly   336 VLANRDKLQQSSE--SRFPIREAFK--NFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNF 396
            ....:.|.|.::|  |...:.:.|:  |.:.:..|..|||..:.||||||||:...|.|:.|...
  Fly   304 YYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLIL 368

  Fly   397 AYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITA 461
            ..:.|||.|.:...:.::||.|||.....|||..|||||...:. |........:.:.|||.|..
  Fly   369 FIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYI-AQGSTTSTAVVMAGKLLIAG 432

  Fly   462 SFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLT 526
            ||.|:|.:::|::||.:|||.:...||..|....|.|...||..:....||:||...|::||...
  Fly   433 SFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWV 497

  Fly   527 LFFPETTNVVLPTTVQEADAIG 548
            :|.|||.|..:|.::::.:..|
  Fly   498 MFLPETMNQPMPESIEDGENFG 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	166/521 (32%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	131/392 (33%)
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	165/520 (32%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	126/378 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070