DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CG8925

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_650526.1	Gene:	CG8925 / 41963	FlyBaseID:	FBgn0038404	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	157/585 - (26%)
Similarity:	242/585 - (41%)	Gaps:	111/585 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPADPAVEVAPPAKD-SEDVTLDAILKHLGQFGRFQLIIFLLIC---LPMMFHA---MFSVTYVF 64
            ||:....| .||::| |:|...|.|...||.:.|:..:..||:|   ||..||.   :|.:|.|.
  Fly    63 PPSAEQTE-QPPSRDLSQDEDSDVISNFLGHYTRWSFLWTLLLCLFQLPTTFHLFMFVFQLTDVR 126

  Fly    65 T--AATVTHRCSVEECDLPGSNYYE------------------------------------PHTN 91
            :  |:.:....::|..||..:...|                                    |...
  Fly   127 SGEASPMLSDGNMENLDLLHTKLLERLLGCLTPWQSMWCALLSIFQAICTFHIFVYVFQIAPKDF 191

  Fly    92 W------------------SIPKNG---KDLDSCN-RYTNSELPQW-NHSVDICSADHFTKNKEA 133
            |                  |...||   .|:|... .|.|::|..| .::.|:        ....
  Fly   192 WCARPENLMQMSVSEWRNISQSSNGCLLLDVDYTQVTYENNQLINWPENATDL--------GYRQ 248

  Fly   134 CAHNEFVFRDDEV-TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGG 197
            |.|.||...|... |:..:|.:.|..: .||:|.|...:|...|..:.|:::||:||..::....
  Fly   249 CWHFEFSDVDGSAKTLVQEFDLVCGRD-ILSLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFV 312

  Fly   198 ILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGE 262
            .:.:|.|.|.:||.|...|:....:....|.|:....||:.:|||..|.|.:...:..:..|:..
  Fly   313 TIQSVFGGILAFSTSVAMFMSLRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISY 377

  Fly   263 VLLAMSAKAFHDWRILLRITYGPSLILLA-YFWILPESVRWLLSQGKEERAKNILRRAAHVN--K 324
            ||.|..|....|||.|......|.||:|: :|| ||||.||||:||:.:....::.|||.:|  .
  Fly   378 VLSAGLAYLIRDWRHLQLAISWPWLIMLSIWFW-LPESPRWLLAQGRLDELCGLIERAARMNGTS 441

  Fly   325 RELPESVLDKLVLANRDKLQQ------SSESRF---------------PIREAFKNFKWRIANCS 368
            ..||.:....|..|....:|.      |.||:.               |:...|....||....:
  Fly   442 ASLPSNYRKTLEAAVPRAVQSPPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWRTTCLT 506

  Fly   369 L-CWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGL 432
            | .|:..:::|:||:|::..|.|:.|.|.|....||.....:.:|::.:.|.|.||.|.||..||
  Fly   507 LVIWLTLIIIYFGLTLHLSNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGL 571

  Fly   433 CCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLA 497
            ||:.|........|:.|.  .:.|..|.|:..::..:.:..|||.:||    |...||...|.:|
  Fly   572 CCLATNLVSNQTGVIALA--TIAKCLIGANNAIIPTYTAMQYPTIVRN----FGVGMGNLASGIA 630

Fly 498 497
Fly 631 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	146/556 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	112/378 (30%)
CG8925	NP_650526.1	MFS	277..667	CDD:119392	109/361 (30%)
CG8925	NP_650526.1	MFS_1	277..635	CDD:284993	109/361 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070