DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CG14856

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	120/540 - (22%)
Similarity:	228/540 - (42%)	Gaps:	42/540 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATV-----THRCSVEECDLPGSNYYE 87
            |.||...|...|:|.::..|..|     .||.|:..:.|..|     .|.|..|:  |...:|.|
  Fly     6 DEILVKCGDSHRYQYMLLALYGL-----LMFIVSRHYFAQNVIGFVPDHWCYHEQ--LENRSYAE 63

  Fly    88 PHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDE--VTISN 150
            ....::..|.    .||.|..:..:          ...:.|.:.|.|  |.:::..|.  ::::.
  Fly    64 IAAIYAPFKR----PSCTRLASINM----------DGSNATASSEPC--NRWIYHYDHGFISMNA 112

  Fly   151 DFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGW 215
            |....|||.:|..:..::..:|...|..:.|.:.||.||..::.|....|.:......|:.:...
  Fly   113 DLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLT 177

  Fly   216 FLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVFYAVGEVLLAMSAKAFHDWRILL 279
            |....|:..:.:.......|::.:|.|.|..|.:..:: :.|||.:|.:..:........||..:
  Fly   178 FSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFM 242

  Fly   280 RITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKL-----VLAN 339
            ..|..|.|::..:::::.||.:||:::...:.|:..|||.|..|:|::.|:..:..     ...:
  Fly   243 VWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKES 307

  Fly   340 RDKLQQSSESRFPIREAFK--NFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALV 402
            ..:.|.|.:.:..:.::||  ..:.|:...::.:.:..|.|..:|.||..|....:..|:..||.
  Fly   308 EARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALT 372

  Fly   403 EIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGT----IFTGADQPVLQLVLFLVGKLTITASF 463
            ..|.......:...|||:::....|.|:||....|    .|.......:.:.|.|:.:..|:.:.
  Fly   373 LPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGISVTT 437

  Fly   464 QVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLF 528
            ......::|:.||.:|:|.|:...:.....|.::|....|..|:..|.:::.....:||..:.|.
  Fly   438 GSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLL 502

  Fly   529 FPETTNVVLPTTVQEADAIG 548
            ..||.|..||.|:.|.:..|
  Fly   503 LSETRNKKLPLTLAEGEEFG 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	114/523 (22%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	84/395 (21%)
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	114/523 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	79/373 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940