Protein Alignment SLC22A and CG14691

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 615
• Identity: 120/615 - (19%)
• Similarity: 194/615 - (31%)
• Gaps: 204/615 - (33%)

  Fly    15 VAPPAKDSEDVTLD--AILKHLGQFGRFQLIIFLLI----CLPMMFHAMFSVTYVFTAATVTHRC 73
            :|..|||:.|...|  ..:...| ||.|.  :|:|.    ||..|..:..:::||..:|
  Fly     1 MADRAKDNTDEPADFETAIAECG-FGLFN--VFILCSAVPCLTAMVFSASALSYVMPSA------ 56

  Fly    74 SVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNE 138
               ||||                                       |:...|.
  Fly    57 ---ECDL---------------------------------------DLSIVDK------------ 67

  Fly   139 FVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVL 203
                                    .|:..:...|........||:||..||...:..||.|....
  Fly    68 ------------------------GMLHAVTYAGMIISAVPWGFIADTIGRRPVLISGGWLDGFF 108

  Fly   204 GVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGE------ 262
            .:..|.|.:....:.|:|.|.:.....::.......|..|.|.|......:.:..::|.
  Fly   109 VLCASLSQNTAQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCVSIGSMILPLL 173

  Fly   263 --------VLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRA 319
                    :|..:|:..|..|::.|.::..|||:.......||||.::|:|||..::|.:.|:|.
  Fly   174 SYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNYKKALDSLQRI 238

  Fly   320 AHVNKRELPESV------------LDKLVLANRDKLQQSSESRFPIR--EAFKNFKWRIANCSLC 370
            ..:|||:..||.            .|.|....|....|...||...:  :.||..|...::
  Fly   239 YKLNKRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQLKPMFSS---- 299

  Fly   371 WIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVE-----IPGFFMPLLIMDRFGRR-YSLCGLM-- 427
                  .|..:||.|..|      :|..|..|.     :|..|..:..||..|.. .|:|.::
  Fly   300 ------PYLAISLQVYCL------HFCQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLEH 352

  Fly   428 -----------------------------LASGLCCIGTI-------FTGADQPVLQLVL----F 452
                                         ..:|:..:|.:       |......:|::.|    |
  Fly   353 NANAKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICIF 417

  Fly   453 LVGKL------TITASFQVLYF------------FASEIYPTNLRNSLLSFCSMMGRFGSMLAPQ 499
            |||.|      .:|.....:|.            .:..|:||.:|..:|......||.||:....
  Fly   418 LVGSLYFVKTSLVTMMVSAVYLTMMGICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSGNM 482

  Fly   500 -TPLLAKYYANAPAMLFAGAAIVSGLLTLF 528
             .|:..:....||.:.......::.|.:||
  Fly   483 LLPVFMQLSCLAPFLWLCSLMSIAFLFSLF 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	96/488 (20%)
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	88/437 (20%)
		MFS	<375..513	CDD:475125	27/138 (20%)