Protein Alignment SLC22A and slc22a2

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_998315.1
• Gene: slc22a2 / 406424
• ZFINID: ZDB-GENE-040426-2167
• Length: 562
• Species: Danio rerio
• Alignment Length: 567
• Identity: 161/567 - (28%)
• Similarity: 254/567 - (44%)
• Gaps: 46/567 - (8%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT 90
            |.:.||:..|.|||.|:.||...||..:..:...|..||...|..|.|..     ||.:......
Zfish     3 TFEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRD-----PGVSEIRERC 62

  Fly    91 NWSIP------------KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKE--------ACA 135
            .||:.            .:|.....|.|:.    ..||.:...|.......|:.        :|.
Zfish    63 GWSLQDARRATVPLINGSSGASYSQCGRFD----VDWNATGLSCENPDGDFNQSQLSVMPMMSCV 123

  Fly   136 HN---EFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGG 197
            ..   ::|.|...||   :|.:.|.|.|.:.|.....::|...|....|::||:|||..|..:..
Zfish   124 DGWEYDYVGRQSFVT---EFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTN 185

  Fly   198 ILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGE 262
            ....|.|::.:.||:|...|||..|........:...:|:..||||...|........:|:::|.
Zfish   186 FFIGVTGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQLFFSMGI 250

  Fly   263 VLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKREL 327
            :||.:.|....:||.|..:...|.:..|.|:|.:|||.||||:|.|...|..|.:..|..|::.|
Zfish   251 LLLPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTL 315

  Fly   328 PESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIAN--CSLCWIVHVLVYYGLSLNVVLLDG 390
            .:    |:.....|.:...|.:.|  .:.||..|.|...  .|..|....:||.||.:.:.:|.|
Zfish   316 SK----KIETLKDDNIDSGSTASF--MDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGG 374

  Fly   391 DKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVG 455
            :.|.:|....:||:|..|:.||.::|.|||.......:.:|..|:.|.|.......|:..:..||
Zfish   375 NVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFIPDSMFWLKSAVACVG 439

  Fly   456 KLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAA 519
            :|.||.:|:::.|..:|:|||.:||..:|.||.:...|.::|| ....||..:...|.::|...|
Zfish   440 RLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGALA 504

  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQS--KSKDLDLVVTA 564
            .|:|.|.|..|||..|.||.|:.:.:.....|::  :|:.|:.::|:
Zfish   505 FVAGGLVLLLPETKGVPLPETIDDIEHPNRNKENPQQSQQLENLMTS 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	120/399 (30%)
slc22a2	NP_998315.1	MFS_SLC22A1_2_3	116..515	CDD:340937	121/407 (30%)