DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and slc22a6l

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	565	Identity:	160/565 - (28%)
Similarity:	250/565 - (44%)	Gaps:	54/565 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNWSI 94
            :|:.:|..||||::...|:.:|::..|..::...|.||...|.|             :||.|.|:
Zfish     6 LLEQVGSTGRFQVLHVTLLSMPILMMASHNLLQNFVAAVPPHHC-------------QPHANLSM 57

  Fly    95 PK---------------NGKDLDSCNRYTNSELPQW-----NHSVDICSADHFTKNKEACAHNEF 139
            ..               ||| |:.|.|||.   |||     |.|..:..........::|....|
Zfish    58 SSTDAMDVLRATVPLGLNGK-LERCKRYTT---PQWQILSLNTSESLWDESMAETETQSCEDGWF 118

  Fly   140 V-FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVL 203
            . ..:...||..::.:.||......|..|....|...|..:.|.::||:||...:.:..::.|:.
Zfish   119 YNMTEMSSTIITEWDLVCDYRALKQMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAIG 183

  Fly   204 GVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMS 268
            |...:||.|:..|.||.....|..|.|....|.:.:|.:..:.|.:..:.....|..|:::||..
Zfish   184 GTCVAFSTSFTMFCVFRVCCGMALSGLVLNSFSLIVEWIPTRVRTVVGTGTGYCYTTGQLILAAV 248

  Fly   269 AKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLD 333
            |....|||.|......|..:...|.|...||.|||:...|.|:|...|:..|.:|.|......:|
Zfish   249 AYCIRDWRWLTLAVSLPFYVSFLYSWWFLESARWLVLTKKPEQAVKNLKTVARINGRSAEGDKID 313

  Fly   334 KLVLANRDKLQQS-SESRFPIREAFKNFKWR-IANC-SLCWIVHVLVYYGLSLNVVLLDGDKYNN 395
            ..:|....|.:.: |:..:...:..:....| |..| |..|......|||||     :|..|:..
Zfish   314 LEMLQESMKKEMACSKGSYSALDLLRTSTMRTITICLSAVWFSTSFAYYGLS-----MDLQKFGV 373

  Fly   396 FAYI-----ALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVG 455
            ..|:     ..|:||...:..:.|...|||.|.||.::.:|:..:..:...:|..:|:..|.::|
Zfish   374 SIYLIQIIFGAVDIPAKIIVTICMSMLGRRPSQCGALVLAGIMILINLLVPSDLQMLRTSLAVIG 438

  Fly   456 KLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAI 520
            |..:.|||...|.:|.|:|||.:|.|.:.:.|||.|||:|:||...||...|...|..::.||.|
Zfish   439 KGCLAASFNCCYLYAGELYPTVIRQSGMGWVSMMARFGAMVAPMVLLLGDDYPWIPGFIYGGAPI 503

  Fly   521 VSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSK---DLDLVV 562
            |||:...|.|||.:..||.|:|:.|..|:.:.:..:   .|||.:
Zfish   504 VSGIFAFFLPETLSQPLPDTIQDIDDRGLARTNSKRLPEKLDLAM 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	152/533 (29%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	115/391 (29%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	152/533 (29%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	116/401 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030