DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and CG7458

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	297/541 - (54%)
Similarity:	383/541 - (70%)	Gaps:	6/541 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AKDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGS 83
            |...||.:|||||..:|||||:|:|.::|:|:||:|:|.||::|||||:||.|||:|.:||.|.|
  Fly    30 AGGDEDNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSS 94

  Fly    84 NYYEPHTNWSIPKNGKDLDSCNRY----TNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDD 144
            .|.|....::|||.....|.|:||    :::.....:.|...|..::||...|.|. .:|.|||:
  Fly    95 VYEEDWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCG-RDFKFRDE 158

  Fly   145 EVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSF 209
            |.|||.:|||:|:|||||||||||||:|||.|||:||:.||||||...:|:.|.:.|::|||||.
  Fly   159 EKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSL 223

  Fly   210 SPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHD 274
            |.:|..||||||||....|||:.|.|::.||||||||||.|.::||:|||:||..|...|.....
  Fly   224 SSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQH 288

  Fly   275 WRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLAN 339
            ||.|||:.|.|:::.:.:.||||||||||||||.||:|.|:|||||.:|:|.|||..|:.|:.:|
  Fly   289 WRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSN 353

  Fly   340 RDKLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEI 404
            |.||.|::||::||..|...|..|||||.|||..|.|:..|||||.|.|.|:||.||.....::|
  Fly   354 RQKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQI 418

  Fly   405 PGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFF 469
            ||..:||:||||.|||:|||..||...:|...:....||.....|.|||:|||.||.|||:||||
  Fly   419 PGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQILYFF 483

  Fly   470 ASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTN 534
            .|||:|||:||:|||.|||:||.|||||||||||||||..||.:|||..|::||.|||.||||.:
  Fly   484 TSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETAD 548

  Fly   535 VVLPTTVQEA-DAIGVKKQSK 554
            .|||||::|| |....|::|:
  Fly   549 KVLPTTIEEARDLNQAKRRSE 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	282/508 (56%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	225/383 (59%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	282/508 (56%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	225/382 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472738
Domainoid	1	1.000	327	1.000	Domainoid score	I3187
eggNOG	1	0.900	-	-		E33208_3BDJJ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	437	1.000	Inparanoid score	I3590
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22082at7147
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm9578
orthoMCL	1	0.900	-	-		OOG6_106230
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11801
	11	10.800