Protein Alignment SLC22A and slc22a4

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_989323.1
• Gene: slc22a4 / 394948
• XenbaseID: XB-GENE-5858686
• Length: 553
• Species: Xenopus tropicalis
• Alignment Length: 535
• Identity: 149/535 - (27%)
• Similarity: 270/535 - (50%)
• Gaps: 31/535 - (5%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNW 92
            |.....||::||:|.:||.|:...::.:....::.:|.|....|||.:.|    .:|......|.
 Frog     5 DEATSFLGEWGRYQFMIFFLLSASIIPNGFNGMSVMFLAGIPEHRCHIPE----SANLSAAWRNA 65

  Fly    93 SIPK-NGKDLDSCNRYTNSELPQWN-------HSVDICSADHFTKNKEACA----HNEFVFRDDE 145
            |||: :|:| ..|.||....|..::       ..||:...:     :|.|.    :::.::..
 Frog    66 SIPRQDGQD-SQCRRYRLGTLTNYSALGLLPGRDVDVTGIE-----QEPCLDGWNYSKSLYLS-- 122

  Fly   146 VTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFS 210
             ||..::.|.|:::||..:..::..:|...|..:.|.::|.:||...:.:...:.....:::.||
 Frog   123 -TIVTEWDIVCENDWKGPLTTSLFFVGVLLGSFVSGQLSDSFGRKKILFVTMAIQTGFSIVQVFS 186

  Fly   211 PSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVIT-VFYAVGEVLLAMSAKAFHD 274
            .|:..|.:...:..|...:.|...|::|.|::|...|::..::.| :|:|:|.::|.:.|....|
 Frog   187 TSWEMFAILFLIVGMGQISNYVAAFILGTEILGKSARIIFSTLGTCIFFAIGYMMLPLFAYFIRD 251

  Fly   275 WRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLAN 339
            ||.||.....|.|..:..:||:|||.:||:.:|:.|.|:.|:|:||.:|:...|..:.....|.:
 Frog   252 WRTLLLALTIPGLFCIPLWWIIPESPQWLICKGRLEEAEVIIRKAAKINRVPAPAVIFKTTELED 316

  Fly   340 RDKLQQSSESRFPIREAFKNFKWRIANCS--LCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALV 402
            ..:.|:.|   :.:.:..|.|..||....  ..|::..:.|:|:|||...|.||.:.|...:|.:
 Frog   317 IAERQKRS---YTLLDLVKTFNVRIITIMTVFLWLITSIGYFGISLNTPNLHGDPFLNCFLLAAI 378

  Fly   403 EIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLY 467
            |:|......|::....||||:||.:|..|:..:.......|..:|..||.:|||..:||:|.::|
 Frog   379 EVPSNIFAWLLLRYISRRYSMCGSLLLGGVVLLLIQLVPLDLQILSTVLVMVGKFGVTAAFSMVY 443

  Fly   468 FFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPET 532
            .:.:|:|||.:||:.:...|:..|.||:::|....|..|....|.:|.....:.:|:|.||||||
 Frog   444 VYTAELYPTVIRNTGVGIGSVSSRIGSVISPYFVYLGAYNRLLPYILMGSLTVANGILVLFFPET 508

  Fly   533 TNVVLPTTVQEADAI 547
            ....||.|:::..:|
 Frog   509 FGKPLPETIEQTQSI 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	111/396 (28%)
slc22a4	NP_989323.1	2A0119	12..516	CDD:273328	145/519 (28%)