Protein Alignment SLC22A and slc22a4

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_957143.1
• Gene: slc22a4 / 393822
• ZFINID: ZDB-GENE-040426-1517
• Length: 553
• Species: Danio rerio
• Alignment Length: 587
• Identity: 169/587 - (28%)
• Similarity: 273/587 - (46%)
• Gaps: 82/587 - (13%)

  Fly    20 KDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSN 84
            :|.:|:|     ..||.:|.|||.:||.:.:.::.:....:..||...|..|.|.:.|    ..|
Zfish     2 RDYDDIT-----SFLGTWGPFQLTVFLALAISILPNGFVGLYIVFVGDTPAHECLIPE----QIN 57

  Fly    85 YYEPHTNWSIPKNGKD----LDSCNRYTNSELPQWNHSVDICSADHFTKN---------KEACA- 135
            ......:.:||...:|    ..||:||....|.|       .|..::|.|         .|.|.
Zfish    58 ISSVWRDAAIPTQMQDGVLKRSSCSRYRLDTLRQ-------LSMLNYTPNVEVNLSQIETEPCVD 115

  Fly   136 ----HNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALG 196
                ..||.    :.||..::.:.|:.|:|..:..:|...|...|..:.|.::|||||...:...
Zfish   116 GWSYSQEFY----QSTIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTM 176

  Fly   197 GILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFY--A 259
            ..|..:..:|:.||||:..|....|....:..:.|...:|:|.|::.|..|||..| :.||.  .
Zfish   177 MALQTITILIQMFSPSWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGS-LGVFMGSG 240

  Fly   260 VGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNK 324
            :|::...::|.....||.|:.......|:....:|.:|||.|||||||:...|:.:|||||..|:
Zfish   241 IGQMFFPLAAYFIRSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNR 305

  Fly   325 RELPESVLDKLVLANRDKLQQSSESRF---PIREAFKNFK--WRIANCSLCWIVHVLVYYGLSLN 384
            ...||      |:.:..:::::::.|.   .|.:...|..  ..|..|||.|:|..:.||.|.||
Zfish   306 VTAPE------VIFSSSEIEEAAKKRIQKHSILDILSNCNAVSTILICSLLWMVITMSYYALILN 364

  Fly   385 VVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQL 449
            ...|.|:.|.||...|:||:|.:.:..|::....||......:|..|    ..||      ::||
Zfish   365 TTNLHGNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGG----ALIF------IIQL 419

  Fly   450 V----------LFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLA 504
            :          |.::|||.:||:|.|:|...||::||.:||..:..|||..|.||:::|....|.
Zfish   420 IPTELQGLATALEMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLG 484

  Fly   505 KYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAI-GVKK---------QSKSKDLD 559
            .||...|.::..|.|:.||:::|..||:...|||.|:.:..:: |:::         :.|||.|.
Zfish   485 NYYRYIPYIVIGGLALFSGVMSLLLPESKGKVLPETIAQMQSVRGLRRCRKPPAASTEDKSKVLQ 549

  Fly   560 LV 561
            .|
Zfish   550 EV 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	125/410 (30%)
slc22a4	NP_957143.1	MFS_SLC22A4_5_OCTN1_2	106..510	CDD:340934	127/424 (30%)