DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and slc22a7b.1

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_021322800.1	Gene:	slc22a7b.1 / 393320	ZFINID:	ZDB-GENE-040426-1311	Length:	560	Species:	Danio rerio

Alignment Length:	576	Identity:	150/576 - (26%)
Similarity:	254/576 - (44%)	Gaps:	56/576 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VTL--DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYE 87
            ||:  |.||.....|||:|:.:.:|:.:|.:......:...|.||..:|.|.:...|..|.....
Zfish     9 VTMKFDNILDETDGFGRYQIALVMLLFIPRITIPCHFLLNNFIAAIPSHHCDISSLDADGLGNLT 73

  Fly    88 PHTNW--SIP--KNGKDLDSCNRYTNSELPQWNHSVDICSAD-----------HFTKNKEACAHN 137
            .....  |:|  ::|... ||:.:.:   ||:...::..|:.           ||.       ::
Zfish    74 QKERLIVSVPAQEDGTPA-SCHMFAH---PQFQLLINSSSSSALPVVECQNGWHFD-------NS 127

  Fly   138 EFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAV 202
            .|:     .|::..|.:.||.........||..:|...|....|.:.|:|||...:.:..:...|
Zfish   128 TFI-----STLATQFDLVCDKRGLAKASATIFFVGVMCGAVFFGVLCDKYGRRSMLLVSYVFSIV 187

  Fly   203 LGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAM 267
            ..|..:||.||..|..|.||..:..:.:.:...|:.||.|..|.|.......::.:::|.:|||.
Zfish   188 FSVTSAFSSSYIMFAAFRFLTGLALTGISNISVVLSIEWVDTKHRTFMGLFGSMSWSIGNMLLAG 252

  Fly   268 SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNK------RE 326
            .|....|||:|:.|...|..:..|.:|.:|:|.|||::.||.|.|...|.:.|..|:      |.
Zfish   253 FAFMVTDWRLLIVIVTAPLFLATATWWWIPDSARWLIANGKTETAYKYLHKCATFNQRLDFTSRV 317

  Fly   327 LPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIAN--CSLCWIVHVLVYYGLSLNVVLLD 389
            .||::...:.:.:|.       ..:...:..|..:.|...  ..:.|......|||:|||:....
Zfish   318 KPETLSTVVTVDHRG-------HSYTYLDLVKTPQLRKLTLFTGIVWYGVASTYYGISLNITGFG 375

  Fly   390 GDKY-NNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFL 453
            .|.| .:|.| |.:|:|...:....:::.|||.:..|.::.:|.|.:..|.|..:....:.|:.:
Zfish   376 LDPYLTHFIY-AAIEVPAKILVYFSLNKVGRRNTQTGTLVLTGFCILINIITPTEYWTFRTVIAV 439

  Fly   454 VGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGA 518
            :||....|||..:..:.:|:|||.:|.:.|.|.:.|.|.|:.::|...||...:...|.::|...
Zfish   440 LGKGLSEASFTTVILYTTELYPTVMRQNGLGFTNFMARMGASISPLIMLLEDIWKLLPEVIFCSM 504

  Fly   519 AIVSGLLTLFFPETTNVVLPTTVQEADAIGVK------KQSKSKDLDLVVTATQAQ 568
            ||..|::.|..|||.|..||.||::.:.:..|      ....:..|.|.:||...|
Zfish   505 AIFCGIIALLLPETNNASLPETVEDIEDMRKKPVYFTTADQSAMPLKLPLTADTTQ 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	137/528 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	107/392 (27%)
slc22a7b.1	XP_021322800.1	Sugar_tr	22..526	CDD:331684	137/527 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010