Protein Alignment SLC22A and SLC22A10

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001034841.3
• Gene: SLC22A10 / 387775
• HGNCID: 18057
• Length: 541
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 142/572 - (24%)
• Similarity: 237/572 - (41%)
• Gaps: 72/572 - (12%)

  Fly    25 VTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYV----FTAATVTHRCSVEECD------ 79
            :..:.:|..:|..||||: :.|:..||.:   |..:.::    |.||...|||.|...|
Human     1 MAFEELLSQVGGLGRFQM-LHLVFILPSL---MLLIPHILLENFAAAIPGHRCWVHMLDNNTGSG 61

  Fly    80 -LPGSNYYEPHTNWSIPKNGKDLDS------CNRYTNSELPQWN--------HSVDICSADHFTK 129
             ..|....:.....|||     |||      |.|:.:   |||.        ||..  .||
Human    62 NETGILSEDALLRISIP-----LDSNLRPEKCRRFVH---PQWQLLHLNGTIHSTS--EAD---- 112

  Fly   130 NKEAC----AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRS 190
             .|.|    .:::..|..   ||...:.:.||.:...|:|..:...|...|..|||.|:||:||.
Human   113 -TEPCVDGWVYDQSYFPS---TIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRR 173

  Fly   191 FSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVIT 255
            |.:....:..|:.....:|:|::..:.|..||...:|..:.|...:...|.:.|..:.|...:.:
Human   174 FILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSS 238

  Fly   256 VFYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAA 320
            ...::|:::|...|..|.||:.|..:...|..:.......|.||.|||:...|.:.....||:.|
Human   239 GALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVA 303

  Fly   321 HVNKRELPESVLDKLVLANRDKLQQ---SSESRFPIREAFKNFKWRIANCSLCWI--VHVLVYYG 380
            ..|..:..|..|:..|:  |..:|:   :::::..:.:.|:|...|...|.|.::  .:.:.:||
Human   304 RTNGIKNAEETLNIEVV--RSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYG 366

  Fly   381 LSLNV------VLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIF 439
            ..:|:      :.|....|...|.|...      :.||.::..|||.|....|...||..:...|
Human   367 TMVNLQHVGSNIFLLQVLYGAVALIVRC------LALLTLNHMGRRISQILFMFLVGLSILANTF 425

  Fly   440 TGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLA 504
            ...:...|::.|..:|.....|:|..:.....|:.||.||...........|.|:.|||....|.
Human   426 VPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMTLT 490

  Fly   505 KYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSK 556
            .::...|.:::....|:.||:....|||.|:.||.|:::.:  ..||..|.|
Human   491 VFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE--NQKKNLKEK 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	136/544 (25%)
		MFS	146..530	CDD:119392	94/394 (24%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	136/544 (25%)
		MFS	143..516	CDD:119392	90/380 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940