Protein Alignment SLC22A and SLC22A25

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_955384.3
• Gene: SLC22A25 / 387601
• HGNCID: 32935
• Length: 547
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 136/562 - (24%)
• Similarity: 232/562 - (41%)
• Gaps: 74/562 - (13%)

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYV-------FTAATVTHRCSVEECDL------- 80
            :|..:|..||||:       |.|:|..||:|...       |.|..:.|||.|...|.
Human     6 LLDQVGGLGRFQI-------LQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDND 63

  Fly    81 PGSNYYEPHTNWSIPKNGKDLDS------CNRYTNSELPQW-----NHSVDICSADHFTKNKEAC 134
            ||:...:.....|||     .||      |.|:.:   |||     |.:....|    ..:.|.|
Human    64 PGTLSQDALLRISIP-----FDSNLRPEKCRRFVH---PQWKLIHLNGTFPNTS----EPDTEPC 116

  Fly   135 AHNEFVFRDDEV--TISNDFGIFCDDEWKLSMVGTINNLGQFF---GIPIG----GFVADRYGRS 190
            . :.:|:.....  ||...:.:.|:.:       .:|::.:|.   |:.:|    |.::||:||.
Human   117 V-DGWVYDQSSFPSTIVTKWDLVCESQ-------PLNSVAKFLFMAGMMVGGNLYGHLSDRFGRK 173

  Fly   191 FSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDN-MTSSTLYSTCFVIGIELVGPKRRVLACSVI 254
            |.:....:..|::|...:|:|:...:....||.. .|.|.:.:|..:| :|.:..:...:|.::.
Human   174 FVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLI-VEWITHQFCAMALTLT 237

  Fly   255 TVFYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRA 319
            ....::|.:.|...|....|..||..:...|..:...:...|.||.|||:...|.|.....||:|
Human   238 LCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELRKA 302

  Fly   320 AHVNKRELPESVLDKLVLANRDKLQ-QSSESRFPIREAFK--NFKWRIANCSLCWIVHVLVYYGL 381
            ||.|..:..|.:|...||.:..|.: ::::.:..:.|..:  |...||...|.......:.::||
Human   303 AHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFASTIPFWGL 367

  Fly   382 SLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPV 446
            :|::..|..:.:........|.:....:....::...||.|...||.....|.:..||...:...
Human   368 TLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQT 432

  Fly   447 LQLVLFLVG----KLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYY 507
            |::||..:|    .|.||.|...    .:|:.|:.:|.............|..||....:|:.|.
Human   433 LRVVLATLGVGAASLGITCSTAQ----ENELIPSIIRGRATGITGNFANIGGALASLMMILSIYS 493

  Fly   508 ANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGV 549
            ...|.:::...||:|||:.|..|||.|..|..::|:.:..||
Human   494 RPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGV 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	93/410 (23%)
SLC22A25	NP_955384.3	MFS_OAT	109..516	CDD:340932	96/423 (23%)