DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CG5592

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	143/556 - (25%)
Similarity:	250/556 - (44%)	Gaps:	61/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PAKDSEDVTLDAILKHLGQFGRFQ-LIIFLLICLPMMFHAMFSVTYVFTAATV----THRCSVEE 77
            |.:|.|  ..:..|..:|.||.|| .::|.:  :|..|  :|:.||......:    .|.|.|.|
  Fly     2 PPRDCE--KYENFLLFIGDFGPFQKRLLFWM--MPAAF--LFAFTYFGQIFMILLPKNHWCRVRE 60

  Fly    78 CD-LPGSNYYEPHTNWSIP-KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFV 140
            .: ||.|.    ..|..|| |.....::|..|   .:|..:::.:..:.   |::...| :|.::
  Fly    61 LEGLPESE----QKNRGIPKKQDGSFENCFMY---NVPYDSNATNDANQ---TRSPIPC-NNGWI 114

  Fly   141 FRDDEV---TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIG----GFVADRYGRSFSIALGGI 198
            :...||   :|:.::...||..    ..||.:.:..|.|..:|    ||:.|..||..::.|...
  Fly   115 YDRKEVPYESIATEYNWVCDKR----DFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANS 175

  Fly   199 LGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVFYAVGE 262
            ...:.|.:......:..|....|:..::.:..:...:::.:|.||.|.|.|..:: :|.|:.:|.
  Fly   176 CSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGA 240

  Fly   263 VLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKREL 327
            .||...|....:||....:...|.:.::....:.|||..||:|.||.:|...:::.||..|.:.:
  Fly   241 CLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKII 305

  Fly   328 PESVLD------KLVLANRDKLQQSSESRFPIREAFKNFKWRIANCSL--CWIVHVLVYYGLSLN 384
            .|.|..      :|..||....:|     :...:.||.|...:....|  .|:...|.|......
  Fly   306 SEEVWSEMRECYELKFANEQLGKQ-----YTSLDLFKTFPRLVVLTILIVTWMTVALAYDAHVRV 365

  Fly   385 VVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQ- 448
            |.:||.|.:..|:..:|||||...:|:|::||.||:..:..:||   ||...::|.|    :|:
  Fly   366 VEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVML---LCAASSLFVG----ILKG 423

  Fly   449 ----LVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYAN 509
                ....:..:...|.::.|...:||||.||.||...|:..::||:.|::|:|......:||..
  Fly   424 HWNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRP 488

  Fly   510 APAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEAD 545
            .|..:....:::..|:.||.|||....:|.|:.||:
  Fly   489 LPMFIITLVSVIGALIILFLPETKGATMPQTLDEAE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	136/532 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	103/404 (25%)
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	136/532 (26%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	97/379 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990