DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a12

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	149/570 - (26%)
Similarity:	252/570 - (44%)	Gaps:	61/570 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC-------SVEECDLPGSNYYE 87
            :|..:|..|||||:..:.:..|:::....::...|:||...|||       |..:..:||....:
  Rat     6 LLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPGDFGRD 70

  Fly    88 PHTNWSIPKNGKDL--DSCNRYTNSELPQWNHSVDICSADHFT-KNKEAC----AHNEFVFRDDE 145
            .....|||. |.|.  ..|.|:..   |||.......:|.::: .:.|.|    .::...||.
  Rat    71 VLLAVSIPP-GPDQRPHQCLRFRQ---PQWQLIESNTTATNWSDADTEPCEDGWVYDHSTFRS-- 129

  Fly   146 VTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFS 210
             ||...:.:.||.:....|..:|...|...|..:.|..:||:||...:....:|.:|.|.|.:..
  Rat   130 -TIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAALM 193

  Fly   211 PSYGWFLVFEFL-------DNMTSSTLYSTCFVIGIE----------------------LVGPKR 246
            |::..:.:|.||       ..|.:::|.....|:|.|                      ..||
  Rat   194 PTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPELTPSLLLAVMEWTSAQAGP-- 256

  Fly   247 RVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEER 311
              |..::..:.::.|:||....|.....||:|......|..:...|.|.||||.|||::.|:.::
  Rat   257 --LMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGRLDQ 319

  Fly   312 AKNILRRAAHVNKRELPESVLDKLVLANRDKLQQ-----SSESRFPIREAFKNFKWRIANCSLCW 371
            :...|:|.|.||:|:.....|...||  |..:|:     .:.:|..........:.|.....|||
  Rat   320 SLRELQRVAAVNRRKAEADTLTVEVL--RSAMQEEPNGNQAGARLGTLLHTPGLRLRTFISMLCW 382

  Fly   372 IVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIG 436
            ......:|||:|::..|..:.:...|.|.:|::|.....||::.|.|||......::..|||.:.
  Rat   383 FAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQASSLVLPGLCILA 447

  Fly   437 TIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTP 501
            .|....:..:|:..|.::|..::.|:|..:..|:||::||.:|.:.:....:..|.|:||.|...
  Rat   448 NILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVR 512

  Fly   502 LLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKK 551
            ||..|.:..|.:::....::|||..|..|||.|:.||.|:|:.....|||
  Rat   513 LLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKK 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	143/552 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	106/417 (25%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	110/440 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346833
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960