DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CG4630

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	606	Identity:	230/606 - (37%)
Similarity:	323/606 - (53%)	Gaps:	96/606 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PAVEVAPPAKDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSV 75
            ||...|....|.:|     ||..:|:|||||...:||||||::|.|..|::|||||.:.|:||.|
  Fly     4 PAAGAASAVLDFDD-----ILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYV 63

  Fly    76 EECD---------------LPGS----NYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDI 121
            .|||               :|||    .::.|.|......||..|:|    ::.....|  .:|.
  Fly    64 PECDKLVDAEYGANWVSIAVPGSWSKRGHFTPSTCERFVANGDHLES----SSDPWSAW--PLDQ 122

  Fly   122 CSADHFTKNKEACAHNEFVFRDDEVTISNDFGIFCDDE-WKLSMVGTINNLGQFFGIPIGGFVAD 185
            |.|::||...|.|  |:||:...|.||...:|:.|.:. |||:.||||:..|...|..:.|::||
  Fly   123 CFAENFTTETERC--NQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLAD 185

  Fly   186 RYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLA 250
            ||||........:..|:.||.::.|..|..||.|..|:.:.:|.:|...|:||:|:|||::|.::
  Fly   186 RYGRKHIFLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMS 250

  Fly   251 CSVITVFYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNI 315
            ..|:..||||||.||.:|. ...|||.|......|.||.:||||::||||||||::.:.|:|..|
  Fly   251 SIVLNYFYAVGEALLGLSV-FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVI 314

  Fly   316 LRRAAHVNKRELPESVL---------------------------DKLVLANRDKLQQSSESRFPI 353
            :||||.||:|::...::                           ||:.||              :
  Fly   315 IRRAAKVNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLA--------------V 365

  Fly   354 REAFKN--FKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDR 416
            :|..::  ...|.|...|.|.|:.:||||||||...|.|:||.|||.:.||||||:.:..|.:.|
  Fly   366 KEVARSHILMGRYAILLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRR 430

  Fly   417 FGRRYSLCGLMLASGLCCIGTIF------------TGADQ-------PVLQLVLFLVGKLTITAS 462
            ||||.:|.|.:|...:.|:.:.|            ||.:.       ..|.:.|||||||.||:|
  Fly   431 FGRRVALSGSLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSS 495

  Fly   463 FQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTL 527
            |.|:|.|.:|:.||.:|:..:...|...|||:||||..||||.||...|.:||...::|:|||:|
  Fly   496 FAVIYTFTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSL 560

  Fly   528 FFPETTNVVLPTTVQEADAIG 548
            ..|||.|..||.||:||.|:|
  Fly   561 LLPETFNRKLPDTVEEAIALG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	217/572 (38%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	163/432 (38%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	217/572 (38%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	145/389 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472739
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35816at33392
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106230
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900