DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and CarT

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	175/591 - (29%)
Similarity:	264/591 - (44%)	Gaps:	82/591 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPADPAVEVAPPAKDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMF-SVTYVFTAATV- 69
            |.:.|:|:        |...||.:|..:|:||::|.::...||||......| :...:|.|.|.
  Fly    24 PESQPSVD--------EAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPD 80

  Fly    70 THRCSVEE-CDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSEL---------PQWNHSVDICSA 124
            .:.|.:.| .|||    .|...:.|||   |:||      |.||         ..|...::....
  Fly    81 DYWCRIPELLDLP----LEQRKSLSIP---KELD------NDELVYSKCYTYGVNWTQLLESGEE 132

  Fly   125 DHFT-----------KNKEACAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTIN----NLGQF 174
            |..|           |..:...:|..|...   :|..||.:.||.:    :..||.    |.|..
  Fly   133 DDLTTMEPNASWPLIKCPQGWEYNTSVVWS---SIVIDFDLVCDQD----IYPTIGLAALNTGGP 190

  Fly   175 FGIPIGGFVADRYGR--SFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVI 237
            .|:.:.|.:.||.||  |:.:.|..:|...|  :.|.|..:..:.....:..:|...:|...|:|
  Fly   191 VGVYLFGLLNDRGGRRLSYFVCLATLLAGSL--MTSLSKDFWTWAGSRVIVGLTIPAVYQIPFII 253

  Fly   238 GIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYF---WILPES 299
            .:||||...|.....:...||..|.:||:.......||   :|::|..||...|||   :::|||
  Fly   254 SLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDW---VRLSYITSLPFYAYFLYMFVMPES 315

  Fly   300 VRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKL-VLANRDKLQQSSES----------RFPI 353
            .||||.:|:.|.|..||.|.|.||.||.||:|..|| ....||||::..:.          |.|
  Fly   316 PRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTP- 379

  Fly   354 REAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFG 418
                 |.:.:....:|.|..:..||.|||.....|..::|.:|...|:||:|.:......||.:|
  Fly   380 -----NMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWG 439

  Fly   419 RRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLL 483
            ||:.|...|:..|:.|:.|:....|.....|||:||.|..::|||.::|.||.|:|||.:|...:
  Fly   440 RRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGI 504

  Fly   484 SFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIG 548
            ...|.:|..|.:..|....|.|.....|.::....:::.|:..|..|||.:..||.|::|.:..|
  Fly   505 GASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFG 569

  Fly   549 VKKQSK 554
            ...|.|
  Fly   570 KNWQFK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	163/547 (30%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	125/403 (31%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	163/547 (30%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	118/379 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.060