DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a15

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	157/546 - (28%)
Similarity:	239/546 - (43%)	Gaps:	96/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LGQFGRFQL-IIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN------ 91
            :|:.|.:|: :.|||..|..::.|..::......||..:...:.|. ||.    :.|:|
  Rat    10 VGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYHWDMAEL-LPN----QSHSNQSSGKG 69

  Fly    92 -----WSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISND 151
                 |.:..||.::.....::||                ||                  :|:::
  Rat    70 QAFGDWLLTANGSEIHKHVHFSNS----------------FT------------------SIASE 100

  Fly   152 FGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWF 216
            :.:..:..:|:|...:....|.|.|:...|.::||:||......|..|..:..:...|||||.:|
  Rat   101 WFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFF 165

  Fly   217 LVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRI 281
            .|..||..|.:..:....||:..|.||.....||.|:..:|:|||....|:.......||.|..:
  Rat   166 AVTRFLVGMMNGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAIL 230

  Fly   282 T--YGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQ 344
            .  .|..:.||:.|  :|||.|||.|||:...|:..|...|..|:                 ||:
  Rat   231 VNLQGTVVFLLSLF--IPESPRWLYSQGRLSEAEEALYLIAKRNR-----------------KLK 276

  Fly   345 QSSESRFPIREAFKN-------FKWRI-----ANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFA 397
            .:.....|...:::.       |::|:     ......|.|..||||||:|:...|.|..|.|.|
  Rat   277 CTFSLTHPANRSYRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLA 341

  Fly   398 YIALVEIPGFFMPL---LIMDR-FGRRYSLCGLMLASGLCCIGTIF------TGADQPVLQLVLF 452
            ...|:|||.:  ||   ||..| |||:.:|...:...||.|:..:|      ||....|....|.
  Rat   342 LSGLIEIPSY--PLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLS 404

  Fly   453 LVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAG 517
            |:|||||:|:|.::|.:.||:|||.:||..|..|||..|.|.::||..|.|.....:.|.::|..
  Rat   405 LLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPSLKDVQWSLPFIVFGA 469

  Fly   518 AAIVSGLLTLFFPETTNVVLPTTVQE 543
            ..:.||||:|..|||.|..|..|..:
  Rat   470 TGLTSGLLSLLLPETLNSPLLETFSD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	156/540 (29%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	129/407 (32%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	122/378 (32%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	116/359 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930