DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and Slc22a17

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_803156.2	Gene:	Slc22a17 / 305886	RGDID:	631405	Length:	520	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	124/547 - (22%)
Similarity:	209/547 - (38%)	Gaps:	125/547 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VFTAATVTHRCSVEECDLPGSNYYEPHTNWSIPKNGKDL-------------DSCNRYTNSELPQ 114
            :||.|...| |.........|.:.:|..:..:...|..|             .||:.:..   |.
  Rat     6 IFTLAPPLH-CHYGALPPNASGWEQPPNSSGVSVAGAALAASAASRVVTSTDPSCSGFAP---PD 66

  Fly   115 WNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISNDFG---IFCDDEWKLSMVGTINNLGQFFG 176
            :||    |..|             :.:....|..:|..|   :.||..|::.:...:..||...|
  Rat    67 FNH----CLKD-------------WDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASG 114

  Fly   177 IPIGGFVADRYGRSFSIALG-GILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIE 240
            ....|:.|||:||...:.|. |::|. .||..:.:.|....:...||.....:.:....:::.:|
  Rat   115 YLFLGYPADRFGRRGIVLLTLGLVGP-CGVGGAAAGSSTGIMTLRFLLGFLLAGVDLGVYLMRLE 178

  Fly   241 LVGPKRRV---LACSVITV---FYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFW--ILP 297
            |..|.:|:   ||..::.|   |..:|   ||:.:|   |||.|.|:...|.::.|.|.|  :..
  Rat   179 LCDPTQRLRVALAGELVGVGGHFLFLG---LALVSK---DWRFLQRMITAPCILFLFYGWPGLFL 237

  Fly   298 ESVRWLLSQGKEERAKNILRRAAHVNK---RELPESVLDKL-VLANRDKLQQSSESRFPIREAFK 358
            ||.|||:.:.:.|.|:::||..|..|:   :.|.|...:.| .|.|...|..:|...|.....::
  Rat   238 ESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQELENTCPLPTTSTFSFASLLNYR 302

  Fly   359 NFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIAL----VEIPGFFMPLLIMDRFGR 419
            |. |:                    |:::|.   :.||...|:    ..:.|...|        .
  Rat   303 NI-WK--------------------NLLILG---FTNFIAHAIRHCYQPVGGGGSP--------S 335

  Fly   420 RYSLCGLMLASGLCCIGTIFTGAD------QPVLQLVLFLVGKLTIT-------------ASFQV 465
            .:.||.| ||||...:..:|.|..      :.:|.|.:.|.|..::.             .:|.|
  Rat   336 DFYLCSL-LASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNDAAITTFSV 399

  Fly   466 LYFF------------ASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGA 518
            |..|            |:|:.||.:|...|.....:|..|.:..|...|...:.|....::.|..
  Rat   400 LGLFSSQASAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHMGHGAFLQHVVLAAC 464

  Fly   519 AIVSGLLTLFFPETTNVVLPTTVQEAD 545
            |::..|..:..|||...:||..:::.:
  Rat   465 ALLCILSIMLLPETKRKLLPEVLRDGE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	124/540 (23%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	103/434 (24%)
Slc22a17	NP_803156.2	MFS	106..476	CDD:119392	97/409 (24%)
Slc22a17	NP_803156.2	2A0114	111..475	CDD:273326	95/403 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100