Protein Alignment SLC22A and Slc22a21

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_008765965.1
• Gene: Slc22a21 / 303140
• RGDID: 1561735
• Length: 555
• Species: Rattus norvegicus
• Alignment Length: 548
• Identity: 154/548 - (28%)
• Similarity: 269/548 - (49%)
• Gaps: 50/548 - (9%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNW 92
            |.:...||::|.||.:||.|:...::.:....::.||..|:..|||.|.:.    .|......|.
  Rat     5 DELTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSAVFLTASPEHRCLVPDT----VNLSSAWRNH 65

  Fly    93 SIP---KNGKDL-DSCNRYTNSELPQWN-------HSVDI-------CSADHFTKNKEACAHNEF 139
            |||   |:|:.: ..|.||..:.:..::       ..||:       | .|.:..:||
  Rat    66 SIPLEMKDGRQVPHKCRRYRLATIANFSALGLEPGEDVDLKQLELENC-LDGWEYSKE------- 122

  Fly   140 VFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLG 204
            ||..   ||..::.:.|:|.||..:..::..:|...|..|.|.::||:||.      .:|...:|
  Rat   123 VFLS---TIVTEWNLVCNDAWKAPLTTSMFYVGVLLGSFISGQLSDRFGRK------PVLFWTMG 178

  Fly   205 V------IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVFYAVGE 262
            :      ::.||.::..|.:...|..|...:.|...||:|.|::....|::..:: |.:|:|.|.
  Rat   179 MHTGFSFLQVFSVNFEMFTLLFALVGMGHISNYVAAFVLGTEILSKSIRIIFATLGICIFFAFGF 243

  Fly   263 VLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKREL 327
            ::|.:.|....|||:||.....|.::..|.:|.:|||.|||:|||:.:.|:.|:|:||..|....
  Rat   244 MVLPLFAYFIRDWRMLLMAITLPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVA 308

  Fly   328 PESVLDKLVLAN-RDKLQQSSESRFPIREAFKNFKWRIANCS--LCWIVHVLVYYGLSLNVVLLD 389
            |.::.|.....| :|...::::|.. |.:..:....||....  :.|:...:.|:||||:...|:
  Rat   309 PSTIFDPSETTNLQDGNAKNTQSHH-IYDLVRTRNIRILTIMSIILWLTISVGYFGLSLDTPNLN 372

  Fly   390 GDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLV 454
            |:.|.|...:|.||:|.:.:..|::....||||:.|.:...|...:......:|...|...|.:|
  Rat   373 GNIYVNGFLLAAVEVPAYVLAWLLLQHVTRRYSMAGSLFLGGSVLLILQLVPSDLLYLSTALVMV 437

  Fly   455 GKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAA 519
            ||..||:::.::|.:.:|:|||.:||..:...|...|.||:|:|....|..|..:.|.::.....
  Rat   438 GKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRHLPYIVMGSLT 502

  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAI 547
            |::.::|.||||::.|.||.|:.|...:
  Rat   503 ILTAIITFFFPESSGVSLPDTIDEMQKV 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	114/403 (28%)
Slc22a21	XP_008765965.1	2A0119	12..523	CDD:273328	150/532 (28%)