DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a22

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	140/544 - (25%)
Similarity:	246/544 - (45%)	Gaps:	36/544 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNY---- 85
            :..|.||.|:|..||||:.:.:::.:..|..::..|...||||...|.|||...|...|..
  Rat     1 MAFDEILHHVGDRGRFQIWMIVVLNILSMVSSLHDVIENFTAAIPAHHCSVNLLDTSRSEISMAM 65

  Fly    86 ---YEPHTNWSIP--KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTK-NKEAC----AHNEFV 140
               .|.....|||  .|.|. :.|.|:.:   |||.......|..:.|: ..|.|    .::..|
  Rat    66 NLTTEAMMKVSIPMGPNQKP-EQCRRFRH---PQWQFIDSNISTSNSTELETEPCLDGWTYDHSV 126

  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205
            |..   ||..::.:.||.:.........:..|.|...|..|.::||:||...:....:...:||.
  Rat   127 FTS---TIVTEWDLVCDFQSFKYYAQATSLAGHFVAAPFCGIISDRFGRKPLLMYCSLAYGILGT 188

  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAK 270
            ..:|.|::..:.|..||.:.::||:...|.::.:|....:.......:..:|.:.|...|...|.
  Rat   189 CCAFVPNFSLYCVLRFLSSASASTVGMNCLILVLEETSVQWHATVIVLSGLFSSTGLAGLGGLAY 253

  Fly   271 AFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-KRELPESVLDK 334
            ...||.::...:..|..|....|..:|||.|||:..||.::|...|:|.|.:| |:::.:::..:
  Rat   254 VLSDWHLIQLTSALPYFIFFILFCWVPESARWLMITGKTDQALKELQRIASINGKKDIAQNLTTE 318

  Fly   335 LVLANRDKLQQ---SSESRFPIREAFKNFKWRIANCSLCW----IVHVLVYYGLSLNVVLLDGDK 392
            .:   |.|:::   |:...|.|::...|  ..|....||:    ...:...:||.|:|.:|..:.
  Rat   319 DL---RSKVKEDVCSTVKHFSIKDIIIN--PMIRKIVLCYSSVLFAELFSIFGLLLDVHMLGKNI 378

  Fly   393 YNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKL 457
            :.....:.:::||...:...|:....||..:..|:.|:|.|...|:|...|..||:|.:|::||.
  Rat   379 FVTQILLGVIDIPSKSLTYFILRNVRRRPLIAFLLFATGGCITITMFLSEDMYVLRLAIFILGKG 443

  Fly   458 TITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGA-AIV 521
            ...|...:...:.:|:.|..||::|......:.|..|:|:..|.:..||:...| |:|.|. .||
  Rat   444 CFAAFISINTAYCNELSPVPLRSTLNGIYISVARLASVLSALTLVTRKYFVLLP-MIFCGVLPIV 507

  Fly   522 SGLLTLFFPETTNVVLPTTVQEAD 545
            :.:...|.|||.|..:..|:::.:
  Rat   508 ATINIYFLPETFNHPITDTIKDME 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	135/527 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	97/392 (25%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	135/527 (26%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	98/397 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950