DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a6

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	142/551 - (25%)
Similarity:	246/551 - (44%)	Gaps:	54/551 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNWSI 94
            :||.:|..||||||...::..|::..|..:....||||...|.|             .|..|.::
  Rat     6 LLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHC-------------RPPANANL 57

  Fly    95 PKNG-----KDLD------SCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEV-- 146
            .|:|     ..||      ||.|:|:   |||.......:..:.|:..|.|. :.:|:.:...
  Rat    58 SKDGGLEAWLPLDKQGQPESCLRFTS---PQWGPPFYNGTEANGTRVTEPCI-DGWVYDNSTFPS 118

  Fly   147 TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSP 211
            ||..::.:.|.......:..::..:|...|..:.|::|||.||...:.|..:..||.|...:::|
  Rat   119 TIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAP 183

  Fly   212 SYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWR 276
            :|..:.||..|..|:.:::...|..:.:|.:....|....::|...|::|:.|||..|.|...||
  Rat   184 NYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWR 248

  Fly   277 ILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKR---------ELPESVL 332
            .|..:...|..|...|.|...||.||..|.|:.:.....|:|.|.:|.:         |:..:.|
  Rat   249 HLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSL 313

  Fly   333 DKLVLANRDKLQQSSESRFP-IREAFKNFKWRIANC-SLCWIVHVLVYYGLSLNVVLLDGDKYNN 395
            .|.:..::.:.......|.| :|..|.        | |:.|......||||.:::.......|..
  Rat   314 QKELTLSKGQASAMELLRCPTLRHLFL--------CLSMLWFATSFAYYGLVMDLQGFGVSMYLI 370

  Fly   396 FAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTIT 460
            ......|::|..|:..|:::..|||.:....:|.:|:|.:..........:::..|.::||..:.
  Rat   371 QVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLA 435

  Fly   461 ASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLL 525
            :||..::.:..|:|||.:|.:.|...|.|.|.||:::|...:.|::|.:.|..:|....:|:..:
  Rat   436 SSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAV 500

  Fly   526 TLFFPETTNVVLPTTVQEADAIGVKKQSKSK 556
            |...|||....||.|||:     :|.:|:.|
  Rat   501 TALLPETLGQPLPDTVQD-----LKSRSRGK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	134/528 (25%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	97/396 (24%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	134/528 (25%)
		MFS	135..505	CDD:119392	94/377 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960