DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a3

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	174/563 - (30%)
Similarity:	276/563 - (49%)	Gaps:	74/563 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVF-------------TAATVTHRCSVEE 77
            |.|..|:..|:|||||..:|||:||..:..|...|..||             .|..:..||:
  Rat     3 TFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCA--- 64

  Fly    78 CDLPGSNYYEPHTNWS-------IPKNGKDLDSCNRY------TNSELPQWNHSVDICSADHFTK 129
                    :.|...|:       :|...:....|:||      |:|||     |.|..:|   ..
  Rat    65 --------WSPEEEWNLTTPELHVPAERRGQGHCHRYLLEDTNTSSEL-----SCDPLAA---FP 113

  Fly   130 NKEA----CAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGR- 189
            |:.|    |: .::.:.:...||.:.|.:.|.:.|.|.:...|.|||...|....|:.||||||
  Rat   114 NRSAPLVPCS-GDWRYVETHSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRL 177

  Fly   190 -SFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV 253
             .:.|:..|:  .:.||:.:|:|::..|::|.||..:.....:.|||||..|:||.|:|.:...|
  Rat   178 IVYLISCFGV--GITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIV 240

  Fly   254 ITVFYAVGEVLLAMSAKAFHDWR-ILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILR 317
            |.:|:.:|.::|...|.....|: |.|.|:. ||.:.|.|:|::|||.|||:::.:.|:|..|||
  Rat   241 IQMFFTLGIIILPGIAYFTPSWQGIQLAISL-PSFLFLLYYWVVPESPRWLITRKQGEKALQILR 304

  Fly   318 RAAHVNKRELPESVLDKLVLANRDKLQQSSES--RFPIREAFKNFKWRIANCSL----CWIVHVL 376
            |.|..|.:.| .|...::.:.:.:....|...  |.|          ::..|:|    .|....:
  Rat   305 RVAKCNGKHL-SSNYSEITVTDEEVSNPSCLDLVRTP----------QMRKCTLILMFAWFTSAV 358

  Fly   377 VYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTG 441
            ||.||.:.:.|:.|:.|.:|....|||:||..:.||.::|.|||.......:.:|:.|:.|.|..
  Rat   359 VYQGLVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLP 423

  Fly   442 ADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPL-LAK 505
            ...|.|:..:..:|:|.||.:|:::|...||:|||.|||..:|.||.:..||.::||.... ||.
  Rat   424 EGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAA 488

  Fly   506 YYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIG 548
            .:...|.::|...|.|.|.|.:..|||..:.||.||::.:.:|
  Rat   489 IWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	168/544 (31%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	129/393 (33%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	168/544 (31%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	125/381 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960