DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a2

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	158/573 - (27%)
Similarity:	263/573 - (45%)	Gaps:	74/573 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYV------FT---------AATVTHRCSV 75
            |:|.||:|:|:|..||...|.|:.|   ....|:..||      ||         ||.::.||..
  Rat     3 TVDDILEHIGEFHLFQKQTFFLLAL---LSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQRCGW 64

  Fly    76 EECDLPGSNYYEPHTNWSIPKNGKD-----LDSCNRYTNSELPQWNHSVDIC-------SADHFT 128
            .:.:         ..|:::|..|..     |..|.||.    ..||.|...|       :||...
  Rat    65 SQAE---------ELNYTVPGLGPSDEASFLSQCMRYE----VDWNQSTLDCVDPLSSLAADRNQ 116

  Fly   129 KNKEACAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSI 193
            .....|.|. :|:.....:|..:|.:.|...|.|.:..::.|:|.|.|..:.|::|||:||.|.:
  Rat   117 LPLGPCEHG-WVYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCL 180

  Fly   194 ALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFY 258
            .:..::.|:.|.:.:.||:|.|.|||.||..:.|...:...:::..|.||...|.:......:.:
  Rat   181 LVTILINAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGICYQIAF 245

  Fly   259 AVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN 323
            .||.::||..|....:||.|......|:...|.|||.:|||.|||:||.|..:|..|::..|..|
  Rat   246 TVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKN 310

  Fly   324 KRELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIAN-------------CSLCWIVHV 375
            .:.:|.|:                ::..|..:|.|..|..|.:             ....|....
  Rat   311 GKSVPVSL----------------QNLTPDEDAGKKLKPSILDLVRTPQIRKHTLILMYNWFTSS 359

  Fly   376 LVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFT 440
            ::|.||.:::.|...:.|.:|.|.||||.|..|:.:|.:||.||||......:.:|..|:.::|.
  Rat   360 VLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFI 424

  Fly   441 GADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLA 504
            ..|...|::.:..:|::.||.:::::....:|:|||.:||..:..||.|...|.::.| ....|.
  Rat   425 PDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRLT 489

  Fly   505 KYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKD 557
            ..:...|.::||...:|:|.|.|..|||....||.|:::|:.:...::.:.|:
  Rat   490 DIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAENMQRPRKKERKE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	150/545 (28%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	113/397 (28%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	150/545 (28%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	107/383 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030