DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a20

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001381833.1	Gene:	Slc22a20 / 293686	RGDID:	1311460	Length:	556	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	152/555 - (27%)
Similarity:	249/555 - (44%)	Gaps:	49/555 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN--- 91
            :|..||..|||||:...|:.||....|..:....||||...|.|.      ..:||.|..||
  Rat     6 LLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQ------HPANYTEATTNDSG 64

  Fly    92 -W---SIPKNGKDL-DSCNRYTNSELPQW--------NHSV--DICSADHFTKNKEACAHNEFVF 141
             |   :||.|...: :.|.|||.   |||        :|.|  :.|        |:...::..:|
  Rat    65 AWLRATIPLNQHGVPEPCQRYTE---PQWALLEPNTSSHGVATEGC--------KDGWVYDRSIF 118

  Fly   142 RDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVI 206
            ..   ||..::.:.|:......:..:|...|...|..:.|.:|||.||...:....:..||.|.:
  Rat   119 PS---TIVMEWDLVCEARTLRDLAQSIYMSGVLVGAALFGSLADRLGRKAPLVWSYLQLAVSGAV 180

  Fly   207 RSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKA 271
            .::..|:..:.:|.||..||.|.:......:.:|.:..:.|.:|..::...:.:|:::||..|..
  Rat   181 TAYVGSFSAYCIFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAGVAYL 245

  Fly   272 FHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELP-ESVLDKL 335
            ...||.|......|.|:...|.|.||||.||||..||.::|...||:.|.:|.|:.. |.:..::
  Rat   246 IRPWRWLQFAVSAPFLVFFLYSWWLPESSRWLLLHGKAQQAVQNLRKVAMMNGRKAEGERLTIEV 310

  Fly   336 V---LANRDKLQQSSESRFPIREAFKNFKWRIANCSL--CWIVHVLVYYGLSLNVVLLDGDKYNN 395
            |   :.|.....::|.|   |.:.|:....|...|.|  .|..:.:.||||::::.......|..
  Rat   311 VSSYIQNEFASVRTSNS---ILDLFRTPGIRKVTCCLMMVWFSNSVAYYGLAMDLQKFGLSIYLV 372

  Fly   396 FAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTIT 460
            .|...:::||...:....|...|||.::...::.:||..|..:|...|...|:.|...:||..:.
  Rat   373 QALFGIIDIPAMLVATTTMIYVGRRATVSSFLVLAGLMVIANMFVPEDLQTLRTVQAALGKGCLA 437

  Fly   461 ASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLL 525
            :||..:|.|..|:|||.:|...:.|.|:..|.|.:.||....|.:.....|.:.|...::::|:.
  Rat   438 SSFICVYLFTGELYPTEIRQMGMGFASVNARLGGLAAPLITTLGEISPVLPPVSFGATSVLAGMA 502

  Fly   526 TL-FFPETTNVVLPTTVQEADAIGVKKQSKSKDLD 559
            .: |..||.||.|..|:...:: .||:....:|.:
  Rat   503 VICFLTETRNVPLVETIAAMES-RVKEGHSKRDTE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	146/529 (28%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	104/390 (27%)
Slc22a20	NP_001381833.1	MFS_SLC22A6_OAT1_like	103..508	CDD:341004	107/418 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950