DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and SLC22A24

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	561	Identity:	148/561 - (26%)
Similarity:	254/561 - (45%)	Gaps:	35/561 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC--------SVEECDLPGSN 84
            |.:|..:|..||||:.:....|:..:......|...|||.|.:|||        :|.:.| .|:.
Human     4 DVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDND-TGTL 67

  Fly    85 YYEPHTNWSIPKNGKDLDS------CNRYTNSELPQWN--HSVDICSADHFTKNKEACAHNEFVF 141
            ..:.....|||     |||      |.|:.:   |||.  | ::....:....:.|.|.......
Human    68 SKDDLLRISIP-----LDSNLRPQKCQRFIH---PQWQLLH-LNGTFPNTNEPDTEPCVDGWVYD 123

  Fly   142 RDDEV-TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205
            |...: ||..::.:.|:.:...|||.::...|...|..|.|.::||.||.....|..:..|:...
Human   124 RSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNT 188

  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAK 270
            ..:|:|::..:.:..||...::.|:....|::.:|...|:.|.:...|:...|:||::||...|.
Human   189 CAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAF 253

  Fly   271 AFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-KRELPESVLDK 334
            |..||.||......|.::|....|.:.||.|||:...:.:.....|||.||:| |:...|::..:
Human   254 AIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTE 318

  Fly   335 LVLANRDKLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLV--YYGLSLNVVLLDGDKYNNFA 397
            ||.:...|...:...:..|...|:..|.|:....||::...:.  :|||.||:..| |...:.|.
Human   319 LVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHL-GSNVSLFQ 382

  Fly   398 YI-ALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITA 461
            .: ..|......:.||.::..|||.|........||..:...|...:..:|::||..:|..:::|
Human   383 ILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSA 447

  Fly   462 SFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLT 526
            :........:|:.||.||:::....::.||.|:.|||....|..|..:.|.:.:....|::..:.
Human   448 ASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVI 512

  Fly   527 LFFPETTNVVLPTTVQEADAIGVKKQSKS-KDLDLVVTATQ 566
            |..|||.::.||.|:|:.:  ..:|.|:: |..|..:..||
Human   513 LLLPETRDLPLPNTIQDVE--NDRKDSRNIKQEDTCMKVTQ 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	138/525 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	101/388 (26%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	104/407 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153807
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950