DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and SPAPB1E7.08c

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_594134.1	Gene:	SPAPB1E7.08c / 2543660	PomBaseID:	SPAPB1E7.08c	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	549	Identity:	107/549 - (19%)
Similarity:	191/549 - (34%)	Gaps:	166/549 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 TKNKEACAHNEFVF-------------RDDEVTISND---------------------------- 151
            :|.:|..:..|.|:             .||::..|||
pombe    17 SKKQEDVSETELVYPVELADATIQPSKSDDDLFDSNDFSKTYLAKSRILSNAMNEIGFGRYQWYL 81

  Fly   152 -----FGIFCDDEW---------KLSMVG-------------TIN-NLGQFFGIPIGGFVADRYG 188
                 ||...|:.|         :|..|.             |:: |||...|..:....||..|
pombe    82 FFVAGFGWMSDNIWPVCTSLILMRLDEVDGPHPPAEGRAPYLTLSQNLGLLVGAMVWSLSADTIG 146

  Fly   189 RSFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV 253
            |.::..|..:...|..||...||::....||:.|.:............|.:|.: |.......:|
pombe   147 RRWAFNLTFLFTGVFAVIAGASPNFASICVFDALWSFGVGGNLPVDSAIFLEAL-PSSHQWLLTV 210

  Fly   254 ITVFYAVGEVLLAM-------------SAKAFH-----DWRILLRITYGPSLILLAYFWILP--E 298
            ::.::|:|:|:..:             .....|     .||..|....|.:|::.|..:::.  |
pombe   211 MSFWWAIGQVIANLVSWGLISNFSCPDDESVCHRADNKGWRYFLFTMGGMTLLMFAARFLVSVYE 275

  Fly   299 SVRWLLSQGKEERAKNILRRAAHVN---------------KRELPESVLDKLVLANRDKLQQSSE 348
            |.::.|::|.:.:|...:.:.|.:|               ::|..||.||....::...:.|.:.
pombe   276 SPKFYLAKGDDYKAVETIHKIARINGKTCTLTVEELYAIDRQEQEESDLDDSKSSDAKSVTQGTT 340

  Fly   349 SRF----------PIREAFKNFKWRIAN--CSLCWIVHVLVY--------YGL----SLNVVLLD 389
            :..          .||:.|.:.|..|::  ..|.|.|..|.:        |.|    :.|..|..
pombe   341 NLIVEKLRKYNFEHIRQCFGSRKLAISSILVILSWAVIGLAFPLYNAFLPYYLETRGNANEPLSV 405

  Fly   390 GDKYNNFAYIALVEIPGFFMP-LLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFL 453
            ...|.|...::.:.:||..:. :|:..|.||:          |..|:..|.||         :||
pombe   406 AKTYRNSLIVSAIGVPGSLIAGVLVEFRIGRK----------GTLCLSLILTG---------VFL 451

  Fly   454 VGKLTITAS-----------------FQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTP 501
            ....|...|                 :.|||.:..|::|:.:|.:.:...:...|...:.:|...
pombe   452 FASTTAKTSNAYLGWNCTFSFFSDIMYGVLYAYTPEVFPSKVRGTAVGLAASANRILGIFSPVIA 516

  Fly   502 LLAKYYANAPAMLFAGAAIVSGLLTLFFP 530
            :.|....:||..:.....|.:|:|.:|||
pombe   517 MRANLTTSAPIFVSGALFIFAGILVVFFP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	107/549 (19%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	99/516 (19%)
SPAPB1E7.08c	NP_594134.1	2A0109	68..552	CDD:129965	98/498 (20%)
SPAPB1E7.08c	NP_594134.1	MFS	122..545	CDD:119392	90/442 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	79	1.000	Domainoid score	I2349
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050