Protein Alignment SLC22A and Slc22a1

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_036829.1
• Gene: Slc22a1 / 24904
• RGDID: 3224
• Length: 556
• Species: Rattus norvegicus
• Alignment Length: 558
• Identity: 169/558 - (30%)
• Similarity: 262/558 - (46%)
• Gaps: 45/558 - (8%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT 90
            |:|.:|:.:|:||.||...|||:||.....|...|..||...|..|     .|..||........
  Rat     3 TVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGH-----YCQNPGVAELSQRC 62

  Fly    91 NWS--------IPKNGKD-----LDSCNRYTNSELPQWNHS----VDICSADHFTKNKE-----A 133
            .||        :|..|..     |..|.||.    ..||.|    ||..|:  ...|:.     .
  Rat    63 GWSQAEELNYTVPGLGPSDEASFLSQCMRYE----VDWNQSTLDCVDPLSS--LVANRSQLPLGP 121

  Fly   134 CAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGI 198
            |.|. :|:.....:|..:|.:.|.|.||:.:..:..|||.|.|..:.|::|||:||...:.:..:
  Rat   122 CEHG-WVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTL 185

  Fly   199 LGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEV 263
            :.:|.||:.:.:|.|...|:|..|..|.|...:.:.:.:..|.||...|.....:..:.:.||.|
  Rat   186 VTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLV 250

  Fly   264 LLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELP 328
            .||..|.|..|||.|......|:.:.|.|:|.:|||.||||||.:..||..|:.:.|..|.: :|
  Rat   251 GLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGK-VP 314

  Fly   329 ESVLDKLVLANRDKLQQSSESRFP-IREAFK--NFKWRIANCSLCWIVHVLVYYGLSLNVVLLDG 390
            .:.|..|.|.     :.:||.|.| ..:.|:  |.:.........|....::|.||.::|.....
  Rat   315 PADLKMLCLE-----EDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGA 374

  Fly   391 DKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVG 455
            :.|.:|.|.:|||.|..|:.|:.:||.||.|.:....|.:|..|:..||...:...|.:.|..:|
  Rat   375 NLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLG 439

  Fly   456 KLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAA 519
            ::..|...|::....:|:|||.:||..:..||.:...|.:..| ....|.:.:...|.:||....
  Rat   440 RMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLG 504

  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKD 557
            :.:|.:||..|||..|.||.|::||:.:| :::||:|:
  Rat   505 LTAGAMTLLLPETKGVALPETIEEAENLG-RRKSKAKE 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	118/397 (30%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	159/530 (30%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)