Protein Alignment SLC22A and Slc22a15

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001034460.2
• Gene: Slc22a15 / 242126
• MGIID: 3607704
• Length: 544
• Species: Mus musculus
• Alignment Length: 581
• Identity: 162/581 - (27%)
• Similarity: 253/581 - (43%)
• Gaps: 106/581 - (18%)

  Fly    34 LGQFGRFQL-IIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN------ 91
            :|:.|.:|: :.|||..|..::.|..::......||..:...:.:. ||.    :.|:|
Mouse    10 VGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYHWDMADL-LPN----QSHSNQTLGKG 69

  Fly    92 -----WSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISND 151
                 |.:..||.::.....::||                ||                  :|:::
Mouse    70 QAFGDWLLTANGSEIHKHVHFSNS----------------FT------------------SIASE 100

  Fly   152 FGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWF 216
            :.:..:..:|:|...:....|.|.|:...|.::||:||......|..|..:..|...|||||.:|
Mouse   101 WFLIANRSYKVSAASSSFFSGVFVGVISFGQLSDRFGRRKVYLTGFALDILFAVANGFSPSYEFF 165

  Fly   217 LVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRI 281
            .|..||..|.:..:....||:..|.||.....||.|:..:|:|||....|:.......||.|..:
Mouse   166 AVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAVL 230

  Fly   282 T--YGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQ 344
            .  .|..:.||:.|  :|||.|||.|||:...|:..|...|..|:                 ||:
Mouse   231 VNLQGTLVFLLSLF--IPESPRWLYSQGRLSEAEEALYFIAKRNR-----------------KLK 276

  Fly   345 QSSESRFPIREAFKN-------FKWRI-----ANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFA 397
            .:.....|...:::.       |::||     ......|.|..||||||:|:...|.|..|.|.|
Mouse   277 CTFSLTHPANRSYRATGSFLDLFRYRILLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLA 341

  Fly   398 YIALVEIPGFFMPL---LIMDR-FGRRYSLCGLMLASGLCCIGTIF------TGADQPVLQLVLF 452
            ...|:|||.:  ||   ||..| |||:.:|...:...||.|:..:|      ||....|....|.
Mouse   342 LSGLIEIPSY--PLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLS 404

  Fly   453 LVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAG 517
            |:|||||:|:|.::|.:.||:|||.:||..|..|||..|.|.::||..|.|.:...:.|.::|..
Mouse   405 LLGKLTISAAFNIVYIYTSELYPTVIRNVGLGACSMFSRVGGIIAPFVPSLKEVQWSLPFIVFGA 469

  Fly   518 AAIVSGLLTLFFPETTNVVLPTTVQE----------ADAIGVKKQSKSKDLDLVVTATQAQ 568
            ..:.||||:|..|||.|..|..|..:          .:|:.::.....:.||.|.:.::.:
Mouse   470 TGLTSGLLSLLLPETLNSPLLETFSDLQMYSYRRLGEEALSLQTLDPPQPLDKVSSESEEE 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	131/417 (31%)
Slc22a15	NP_001034460.2	MFS_SLC22A15	71..469	CDD:340935	133/452 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	513..544		3/18 (17%)