DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a26

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	574	Identity:	146/574 - (25%)
Similarity:	258/574 - (44%)	Gaps:	64/574 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLI--IFLLIC-LPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN 91
            :|..:|..||||::  .||||| :..|.|.:..   .||||.:.|||.|...|    |....:.|
Mouse     6 LLNLVGSHGRFQILQMAFLLICNVITMPHVILE---NFTAANLGHRCWVHIID----NDTNSNNN 63

  Fly    92 -----------WSIPKNGKDLDS------CNRYTNSELPQWNHSVDICSADHFTK-NKEAC---- 134
                       .|||     |||      |.|:..   |||:......|..:.|: :.|.|
Mouse    64 SGILSQDDLLRISIP-----LDSNLRPEKCRRFVQ---PQWHLLQFNGSFSNMTEPDTEPCMDGW 120

  Fly   135 AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL 199
            .:::..|....||   ::.:.|..:...|:...|..:|...|..:||.::|::||........:.
Mouse   121 VYDQRTFLSTTVT---EWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQ 182

  Fly   200 GAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVL 264
            .|:.|...:.:|::..:.:..||..:....:.:...::.:|...||.:.|..::....:..|.::
Mouse   183 MAITGTCTALAPTFFIYCLLRFLTGLCIIPINTNSVLLMLEWTSPKTQALVTTLSMSSHHFGGLI 247

  Fly   265 LAMSAKAFHDWRILLRITYGPSLILL--AYFWILPESVRWLLSQGKEERAKNILRRAAHVNKREL 327
            ||..|.||.:|..|......|..:||  ...| |.||.|||:...|.::|...||:.|..|..:.
Mouse   248 LAGLAFAFQNWHHLQLAISVPIFVLLIPTSRW-LTESARWLIVTNKPQKALQELRKVASKNGIKN 311

  Fly   328 PESVLD----KLVLANRDKLQQSSESRFPIREAF--KNFKWRIANCSLCWI--VHVLVYYGLSLN 384
            .|.||.    :.::.:...:.::..|   :|:.|  .|.:.|:  |.||.:  :.:....|:::|
Mouse   312 SEDVLTMEVVRTIMKDEIAIPRTKPS---LRDLFHMPNLRKRL--CLLCLLRFLQISPTVGINMN 371

  Fly   385 VVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQL 449
            :..|.|:.:...:..:...||...:...:::..|||.|.....|..|:..:..:....:...|.:
Mouse   372 LQHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIFLLSIVSVPQEMQTLLV 436

  Fly   450 VLFLV--GKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPA 512
            ||..:  |...:..:..|||  :||:.||.:|.:.|....:.|..|:.|:|...:|..|.|:.|.
Mouse   437 VLITLAGGSSAMIYNSNVLY--SSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSASLPW 499

  Fly   513 MLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVVTATQ 566
            :::...:|:.|||.|..|||.|..||.::|:.:. |.:...:.|:.|:::..||
Mouse   500 IIYGVLSILGGLLPLILPETKNQPLPDSIQDVEC-GWESSKQKKEEDVIIKVTQ 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	139/541 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	94/395 (24%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	93/407 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940