DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and SV2C

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	647	Identity:	127/647 - (19%)
Similarity:	213/647 - (32%)	Gaps:	243/647 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEF------------------VF- 141
            |:.::|:|..|....||.| .:.:.|          :.|.|..|                  ||
Human   118 KDRRELESERRADEEELAQ-QYELII----------QECGHGRFQWALFFVLGMALMADGVEVFV 171

  Fly   142 -------RDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL 199
                   .:.::.|.|.     ...|    :|:|..||...|....|.:||:.||..|:.:...:
Human   172 VGFVLPSAETDLCIPNS-----GSGW----LGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSV 227

  Fly   200 GAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVL 264
            ......:.||...||:||....|..........|.|....|::..::|....|.:.:|:.:|.:.
Human   228 NGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIY 292

  Fly   265 LAM----------------SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAK 313
            .:.                ||..||.||:.:.:...|.:..:.....:|||.|:||..||.:.|.
Human   293 ASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 357

  Fly   314 NILR--------------RAAHVNKRELPESVLDKLVLANRDK--------LQQSSE-------- 348
            .||:              :...|||.:.|:.: |:|:....|.        ::..:|
Human   358 MILKLIHDTNMRARGQPEKVFTVNKIKTPKQI-DELIEIESDTGTWYRRCFVRIRTELYGIWLTF 421

  Fly   349 ---SRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSL---NVVL-------------LDGDKYN 394
               ..:|:|:       .....::.|......|||||:   :|:.             ::.|||.
Human   422 MRCFNYPVRD-------NTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYA 479

  Fly   395 NFA-------------------------------------------------------------- 397
            ||.
Human   480 NFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDN 544

  Fly   398 --------------------------------YIA-----------LVEIPGFFMPLLIMDRFGR 419
                                            |.|           |..:||..:..|:|||.||
Human   545 TDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGR 609

  Fly   420 RYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLR----- 479
            ...|.|.|:.||:.|. .::.|..:.::..:|.|...|||:| :..|.....|:|||:.|
Human   610 LTMLGGSMVLSGISCF-FLWFGTSESMMIGMLCLYNGLTISA-WNSLDVVTVELYPTDRRATGFG 672

  Fly   480 --NSLLSFCSMMGR--FGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVL 537
              |:|....:::|.  |||:::     :.|   :.|.:|.:...:..||:.|..|:|...||
Human   673 FLNALCKAAAVLGNLIFGSLVS-----ITK---SIPILLASTVLVCGGLVGLCLPDTRTQVL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	127/647 (20%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	110/562 (20%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	127/647 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		3/9 (33%)
		MFS	155..719	CDD:119392	112/590 (19%)
		Pentapeptide_3	507..561	CDD:290309	0/53 (0%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		0/43 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910