Protein Alignment SLC22A and Slc22a5

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_035526.1
• Gene: Slc22a5 / 20520
• MGIID: 1329012
• Length: 557
• Species: Mus musculus
• Alignment Length: 568
• Identity: 158/568 - (27%)
• Similarity: 277/568 - (48%)
• Gaps: 71/568 - (12%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT-- 90
            |.:...||::|.||.:||.|:...::.:....::.||.|.|..|||.|            |||
Mouse     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLV------------PHTVN 57

  Fly    91 ------NWSIP---KNGKDL-DSCNRYTNSELPQWN-------HSVDICSADHFTKNKEAC---- 134
                  |.|||   |:|:.: ..|.||..:.:..::       ..||:...:     :|:|
Mouse    58 LSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLE-----QESCLDGW 117

  Fly   135 AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL 199
            .:::.||..   ||..::.:.|.|:||..:..::..:|...|..|.|.::||:||.      .:|
Mouse   118 EYDKDVFLS---TIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRK------NVL 173

  Fly   200 GAVLGV------IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVF 257
            ...:|:      ::.||.::..|.|...|..|...:.|...||:|.|::....|::..:: :.:|
Mouse   174 FLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIF 238

  Fly   258 YAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHV 322
            ||.|.::|.:.|....|||:||.....|.::..|.:|.:|||.|||:|||:.:.|:.|:|:||.:
Mouse   239 YAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKI 303

  Fly   323 NKRELPESVLDKLVLANRDKLQQSSESRFPIREAF-----KNFKWRIANCSLCWIVHVLVYYGLS 382
            |....|.::.|.      .:||..:.::..:...:     :|.:.......:.|:...:.|:|||
Mouse   304 NGIVAPSTIFDP------SELQDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLS 362

  Fly   383 LNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVL 447
            |:...|.||.|.|...:|.||:|.:.:..|::....||||:...:...|...:......::...|
Mouse   363 LDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYL 427

  Fly   448 QLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPA 512
            ...|.:|||..||:::.::|.:.:|:|||.:||..:...|...|.||:|:|....|..|....|.
Mouse   428 STALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPY 492

  Fly   513 MLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAI-GVKK---QSKSK 556
            :|.....|::.:|||||||:..|.||.|:.:...: |:|:   ||:::
Mouse   493 ILMGSLTILTAILTLFFPESFGVPLPDTIDQMLRVKGIKQWQIQSQTR 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	114/405 (28%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	151/539 (28%)