Protein Alignment SLC22A and Slc22a3

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_035525.1
• Gene: Slc22a3 / 20519
• MGIID: 1333817
• Length: 551
• Species: Mus musculus
• Alignment Length: 565
• Identity: 174/565 - (30%)
• Similarity: 275/565 - (48%)
• Gaps: 78/565 - (13%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVF-------------TAATVTHRCSVEE 77
            |.|..|:..|:|||||..:|||:||..:..|...|..||             .|..:..||:
Mouse     3 TFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCA--- 64

  Fly    78 CDLPGSNYYEPHTNWS-------IPKNGKDLDSCNRY------TNSELPQWNHSVDICSADHFT- 128
                    :.|...|:       :|...:....|:||      |:|||          |.|..|
Mouse    65 --------WSPEEEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSEL----------SCDPLTA 111

  Fly   129 -KNKEA----CAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYG 188
             .|:.|    |: .::.:.:...||.:.|.:.|.:.|.|.:...|.|||...|....|:.|||||
Mouse   112 FPNRSAPLVSCS-GDWRYVETHSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYG 175

  Fly   189 R--SFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLAC 251
            |  .:.|:..|:  .:.||:.:|:|::..|::|.||..:.....:.|||||..|:||.|:|.:..
Mouse   176 RLIIYLISCFGV--GITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVG 238

  Fly   252 SVITVFYAVGEVLLAMSAKAFHDWR-ILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNI 315
            .||.:|:.:|.::|...|.....|: |.|.|:. ||.:.|.|:|::|||.|||:::.:.|:|..|
Mouse   239 IVIQMFFTLGIIILPGIAYFTPSWQGIQLAISL-PSFLFLLYYWVVPESPRWLITRKQGEKALQI 302

  Fly   316 LRRAAHVNKRELPESVLDKLVLANRDKLQQSSES--RFPIREAFKNFKWRIANCSL----CWIVH 374
            |||.|..|.:.| .|...::.:.:.:....|...  |.|          ::..|:|    .|...
Mouse   303 LRRVAKCNGKHL-SSNYSEITVTDEEVSNPSCLDLVRTP----------QMRKCTLILMFAWFTS 356

  Fly   375 VLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIF 439
            .:||.||.:.:.|:.|:.|.:|....|||:||..:.||.::|.|||.......:.:|:.|:.|.|
Mouse   357 AVVYQGLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAF 421

  Fly   440 TGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPL-L 503
            .....|.|:..:..:|:|.||.:|:::|...||:|||.|||..:|.||.:..||.::||.... |
Mouse   422 LPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRL 486

  Fly   504 AKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIG 548
            |..:...|.::|...|.|.|.|.:..|||..:.||.||::.:.:|
Mouse   487 AAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLG 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	168/546 (31%)
		MFS	146..530	CDD:119392	129/393 (33%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	168/546 (31%)
		MFS	145..513	CDD:119392	125/381 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960