Protein Alignment SLC22A and Slc22a2

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_038695.1
• Gene: Slc22a2 / 20518
• MGIID: 1335072
• Length: 553
• Species: Mus musculus
• Alignment Length: 558
• Identity: 167/558 - (29%)
• Similarity: 269/558 - (48%)
• Gaps: 34/558 - (6%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC-SVEECDLPGSNYYEP- 88
            |:|.||:|:|:|..||...|.|:.|.........|..||...|..|.| |....:|.....:.|
Mouse     3 TVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPNHHCRSPGVAELSQRCGWSPA 67

  Fly    89 -HTNWSIPKNGKD-----LDSCNRYTNSELPQWNHSVDIC-------SADHFTKNKEACAHNEFV 140
             ..|:::|..|..     |..|.||.    ..||.|...|       :|:........|.|. :|
Mouse    68 EELNYTVPGLGSAGEVSFLSQCMRYE----VDWNQSTLDCVDPLSSLAANRSHLPLSPCEHG-WV 127

  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205
            :.....:|..:|.:.|...|.|.:..::.|:|.|.|....|::|||:||.|.:.:..::.|:.||
Mouse   128 YDTPGSSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLLVTILINAISGV 192

  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELV--GPKRRVLACSVITVFYAVGEVLLAMS 268
            :.:.||:|.|.|||.||..:.|...:...:::..|.|  |.:|.|..|..|.  :.||.::||..
Mouse   193 LMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIA--FTVGLLILAGV 255

  Fly   269 AKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLD 333
            |.|..:||.|......|:...|.|||.:|||.|||:||.|..:|..|::..|..|.:.:|.|:
Mouse   256 AYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSL-- 318

  Fly   334 KLVLANRD---KLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNN 395
            :.:.|:.|   ||..|........:..|:....:.|    |....::|.||.:::.|...:.|.:
Mouse   319 QSLTADEDTGMKLNPSFLDLVRTPQIRKHTLILMYN----WFTSSVLYQGLIMHMGLAGDNIYLD 379

  Fly   396 FAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTIT 460
            |.|.||||.|..|:.:|.:||.||||......:.:|..|:.::|...|...|::.:..:|::.||
Mouse   380 FFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITVACLGRMGIT 444

  Fly   461 ASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAAIVSGL 524
            .:::::....:|:|||.:||..:..||.|...|.::.| ....|...:...|.::||...:|:|.
Mouse   445 IAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAGG 509

  Fly   525 LTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVV 562
            |.|..|||....||.|:::|:.:...::.|.|.:.|.|
Mouse   510 LVLLLPETKGKALPETIEDAEKMQRPRKKKEKRIYLQV 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	122/399 (31%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	156/525 (30%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15244	284..288		3/3 (100%)