Protein Alignment SLC22A and Slc22a1

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_033228.2
• Gene: Slc22a1 / 20517
• MGIID: 108111
• Length: 556
• Species: Mus musculus
• Alignment Length: 551
• Identity: 167/551 - (30%)
• Similarity: 266/551 - (48%)
• Gaps: 31/551 - (5%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC-SVEECDLPGSNYYEP- 88
            |:|.:|:|:|:||.||...|||:||.....|...|..||...|..|.| |....:|.....:.|
Mouse     3 TVDDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPA 67

  Fly    89 -HTNWSIPKNGKD-----LDSCNRYTNSELPQWNHSVDIC-------SADHFTKNKEACAHNEFV 140
             ..|:::|..|..     |..|.:|.    ..||.|...|       :|:........|.|. :|
Mouse    68 EELNYTVPGLGSAGEASFLSQCMKYE----VDWNQSTLDCVDPLSSLAANRSHLPLSPCEHG-WV 127

  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205
            :.....:|..:|.:.|.|.||:.:..:..|||.|.|..:.|::|||:||...:.:..::.::.||
Mouse   128 YDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGV 192

  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAK 270
            :.:.:|.|...|:|..|..|.|...:.:.:.:..|.||...|.....:..|.:.||.|.||..|.
Mouse   193 LTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAY 257

  Fly   271 AFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKL 335
            |..|||.|......|:.:.|.|:|.:|||.||||||.:..:|..|:.:.|..| |::|.:.|..:
Mouse   258 AIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKN-RKVPPADLKMM 321

  Fly   336 VLANRDKLQQSSESRFP-IREAFKNFKWRIANCSL--CWIVHVLVYYGLSLNVVLLDGDKYNNFA 397
            .|.     :.:||.|.| ..:.|:....|.....|  .|....::|.||.::|.....:.|.:|.
Mouse   322 CLE-----EDASERRSPSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANLYLDFF 381

  Fly   398 YIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITAS 462
            |.:|||.|..|:.|:.:||.||.|.:....|.:|..|:..||...:...|.:.|..:|::..|..
Mouse   382 YSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRMGATIV 446

  Fly   463 FQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAAIVSGLLT 526
            .|::....:|:|||.:||..:..||.:...|.:..| ....|.:.:...|.:||....:.:|.:|
Mouse   447 LQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLSAGAVT 511

  Fly   527 LFFPETTNVVLPTTVQEADAIGVKKQSKSKD 557
            |..|||..|.||.|::||:.:| :::||:|:
Mouse   512 LLLPETKGVALPETIEEAENLG-RRKSKAKE 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	118/397 (30%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	156/523 (30%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)