DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a8

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	532	Identity:	144/532 - (27%)
Similarity:	246/532 - (46%)	Gaps:	39/532 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPH 89
            :|...||..:|..|.||.:...|:.||::..|..::..:|||.|..|.|..     |.:...||
Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRP-----PPNASLEP- 59

  Fly    90 TNWSIP--KNGKDLDSCNRYT---NSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTIS 149
              |.:|  .|||. :.|.|:.   |:.||.     |...|      .|.|. :.:::.....||.
Mouse    60 --WVLPLGPNGKP-EKCLRFVHLPNASLPN-----DTQGA------TEPCL-DGWIYNSTRDTIV 109

  Fly   150 NDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYG 214
            .::.:.|.......|..::...|...|.|:.|.::||:||...:....:|.|..|...:||||..
Mouse   110 TEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLT 174

  Fly   215 WFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILL 279
            .:::|.||...:.|.:..:..::.:|.|....|.::.:.|...|.:|:.:|...|.|...||.|.
Mouse   175 VYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQ 239

  Fly   280 RITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-KRELPESVLDKLVLANRDKL 343
            ........|.....|.:|||:|||:..||..:|...|:|.|..| |:|..|.:..:.:..|..|.
Mouse   240 LSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKD 304

  Fly   344 QQSSESRFPIREAFK-NFKWRIANC-SLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIAL----- 401
            ..|::.::.:.:.|: :...|:..| ||.|......||.|::.|     :::....||..
Mouse   305 ITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGV-----EEFGVNIYILQIIFGG 364

  Fly   402 VEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVL 466
            |:||..|:.:|.:...|||.:...|::.:|:..:..||..::..:|:..|.:.||..::.||..|
Mouse   365 VDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCL 429

  Fly   467 YFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPE 531
            :.:.||:|||.||.:.:...::..|.|||:||...:..:.....|.::|....::.|....|..|
Mouse   430 FLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLE 494

  Fly   532 TTNVVLPTTVQE 543
            |.|..||.|:::
Mouse   495 TLNRPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	140/517 (27%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	104/391 (27%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	140/517 (27%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030