Protein Alignment SLC22A and Slc22a25

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_620263.1
• Gene: Slc22a25 / 192273
• RGDID: 621104
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 575
• Identity: 144/575 - (25%)
• Similarity: 260/575 - (45%)
• Gaps: 71/575 - (12%)

  Fly    30 ILKHLGQFGRFQ------LIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLP------- 81
            :|..:|..||||      ::||.:|..|   |::..   .|||....|||.|...|..
  Rat     6 LLNQVGSLGRFQILQMTFILIFNIIISP---HSLLE---NFTAVIPNHRCWVPILDNDTVSGNDN 64

  Fly    82 GSNYYEPHTNWSIPKNGKDL--DSCNRYTNSELPQWN--HSVDICSADHFTK-NKEAC----AHN 137
            |:...:.....|||.: .||  :.|.|:..   |||:  |.....|:  .|: :.|.|    .::
  Rat    65 GNLSQDDLLRVSIPLD-SDLRPEKCRRFVQ---PQWDLLHLNGTFSS--VTEPDTEPCVDGWVYD 123

  Fly   138 EFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFF---GIPIG----GFVADRYGRSFSIAL 195
            :..|..   ||..::.:.|:.:       :::::.:|.   ||.:|    |.:.||:||...:..
  Rat   124 QSTFLS---TIITEWDLVCESQ-------SLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILIC 178

  Fly   196 GGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAV 260
            ..:..||.....:|:|::..:....||..::.||:.:...::.||...||.:.||..::....|:
  Rat   179 ASLQMAVTETCAAFAPTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAI 243

  Fly   261 GEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKR 325
            |:.:||..|....:|..|......|...||.....|.||.|||:...|.::....|.:.||:|..
  Rat   244 GQTVLAGLAFTVRNWHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGM 308

  Fly   326 ELPESVLDKLVLAN--RDKLQQSSESRFPIREAFK--NFKWRIANCSL----CW--IVHVLV-YY 379
            :....||...|:..  :::| ::|:::..:.:.|:  |.:.||...||    .|  ::.:|: :.
  Rat   309 KNSTDVLTIEVVRTIMKEEL-EASQTKSSLWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQ 372

  Fly   380 GLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQ 444
            .|.:||.||.       ..:.::.||...:.:.:::..|||.|...::...|:..:..||...:.
  Rat   373 HLRINVFLLQ-------CLLGIITIPANLVGIFLVNHLGRRISQLFIISLFGISILAIIFVPQEM 430

  Fly   445 PVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYAN 509
            .:|::||...|.:....|.......|:|:.||.:|.:.|....:.|..|:.|:|...:|..|..:
  Rat   431 QILRMVLATFGGVFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDS 495

  Fly   510 APAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIG-VKKQSKSKDLDLVVT 563
            .|.:::...:.:.||:.|..|||.|..||.::|:.:..| ..:|.|..|..:.||
  Rat   496 LPWIIYGVLSFLGGLVVLLLPETKNQPLPDSIQDVENEGRASRQGKQNDTLIKVT 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	96/411 (23%)
Slc22a25	NP_620263.1	MFS_OAT	109..506	CDD:340932	96/414 (23%)