Protein Alignment SLC22A and Y66D12A.13

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_499489.1
• Gene: Y66D12A.13 / 190497
• WormBaseID: WBGene00013439
• Length: 533
• Species: Caenorhabditis elegans
• Alignment Length: 576
• Identity: 130/576 - (22%)
• Similarity: 244/576 - (42%)
• Gaps: 112/576 - (19%)

  Fly    40 FQLIIFLLICLP----MMFHAMFSVTY-VFTAATVTHRCSVEECDLPGSN--YYEPHTNWSIPKN 97
            |:|..:.|:.|.    ::|..:.:|.: :|.||...         |||.:  .|    |.:.|
 Worm    10 FELDAYQLVVLAFNEFLIFTMLSNVVFNMFGAAAPR---------LPGCDDIIY----NATSP-- 59

  Fly    98 GKDLDSCNRY---TNSELPQWNHSVDICSADHFTKNKEACA-HNEFVFRDDEVTISNDFGIFCDD 158
               ...|.:|   .:.|.|...:.....:.:.    :|.|: |||..:.|   :|:..||:  ::
 Worm    60 ---FQQCEQYDAHLDCEEPAMEYEFKSVAVEF----QELCSRHNEHSYMD---SITQLFGV--NN 112

  Fly   159 EWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLD 223
            ..:.|.  |...:|...|..|.|.::|.|||.....|...:........|||.|...|::..|..
 Worm   113 RVRFST--TSQMIGIMLGSAIAGQLSDLYGRKKITLLFLCMMLFFSTSSSFSSSIEVFIIVRFFI 175

  Fly   224 NMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRITYGPSLI 288
            .:....|.:...::.:|.:....|:...:|:|  :|...:|.|:.|....:||.|.|:....::|
 Worm   176 GICCGGLTTVGSILVVENLPSAHRLWMSTVVT--WAPNYMLFALFAYITGEWRCLARMCNAMTVI 238

  Fly   289 -LLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNK-----RELPESVLDKLVLANRDKLQQSS 347
             :|...::||||.::|:   :..:.|..::...::||     .:|.::.::.:|   ...::..:
 Worm   239 AILICAFLLPESPKYLI---QARKGKLAVKSIKYINKFKRVRNQLTDTEIEDVV---HSAIEVDT 297

  Fly   348 ESRFPIRE-AFKNF--------KWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVE 403
            :||...:: :|.:.        :..:|:.|:..:.:|.  |||..|..:|.|..|.|.|
 Worm   298 KSRAKAKKYSFIHLYIHPKITVQTVVASISMFSVSYVT--YGLLFNYDVLTGSIYMNAA------ 354

  Fly   404 IPGFFMPLL-----IMDRFG----RRYSLCGLMLASGLCCI-GTIFTGADQPVLQ-------LVL 451
            :.||...::     ::|.||    .|..:..:.::..:||: |..|...:..||:       |.|
 Worm   355 VSGFLRYVVGAVVAVLDHFGGEHVGRKRMHFITVSFIMCCMFGIFFIYFNDLVLEYKSWIRALTL 419

  Fly   452 FLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFA 516
            ...|  |....|..|....:|::||.:||...:..::.||.|::..   |::..|     .:.||
 Worm   420 LAFG--TTGCLFLQLLLITAEMFPTGIRNIASAHINVCGRLGNVFG---PMVFSY-----KLGFA 474

  Fly   517 GAA-IVSGLLTL--------FFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVVT 563
            |:. ::.|::.|        |.|||.|..||..:...     |||.|..::...:|
 Worm   475 GSGYLILGVICLLDVIVFHIFIPETKNQPLPQGMPSR-----KKQRKDPEVQKSLT 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	98/434 (23%)
Y66D12A.13	NP_499489.1	2A0119	36..506	CDD:273328	118/524 (23%)