Protein Alignment SLC22A and T12B3.2

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_501177.1
• Gene: T12B3.2 / 188439
• WormBaseID: WBGene00020445
• Length: 478
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 122/524 - (23%)
• Similarity: 208/524 - (39%)
• Gaps: 117/524 - (22%)

  Fly    54 FHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN----WSIPKNGKDLDSCNRYTNSELPQ 114
            ||....:|:.|...            ..|.|.:..::|    |.. .:.|....||.|.
 Worm     8 FHICAFITWQFANF------------FAGQNIFGIYSNNVSKWKC-GDSKPTKDCNIYL------ 53

  Fly   115 WNHSVDICSADHFTKNKEACAHNEFVFRDDEV-TISNDFGIFCDDE-WKLSMVGTINNLGQFFGI 177
                              :|..:...|.|... :.:.:|...|... :..|....:..:|...|.
 Worm    54 ------------------SCPKSNLTFVDPPFQSAAIEFDWICGSSVFYQSFFSQVQYVGVLIGT 100

  Fly   178 PIGGFVADRYGRSFSIALGGILGAVLGVIRS-FSPSYGWFLVFEFLDNMT-SSTLYSTCFVIGIE 240
            .:.|.::||:||. .|.:..|..|:.....| .:||........||..:: ...|...|..| :|
 Worm   101 LLFGSLSDRFGRR-PIGILVISNAICSTFASGLAPSVKILFPLRFLVGLSIGGMLVVICAWI-ME 163

  Fly   241 LVGPKRRVLACSVITVFYAVGEVLLAMSAKAF--HDWRILLRITYGPSL----ILLAYFWILPES 299
            ::.|::|:    |:..|:..|...:.:::..:  .:||:   .||..||    .||...:::|||
 Worm   164 VILPQQRM----VVRGFFNWGWTRIFLTSICYFTREWRL---ATYVSSLSLIPALLLVIFVIPES 221

  Fly   300 VRWLLSQGKEER---AKNILRRAAHV------NKRELPESVLDKLVLANRDKLQQSSESRFPIRE 355
            ..||.|:|.:.|   ::..:.|.|.|      :|...|:|::|.|            :::...::
 Worm   222 PVWLHSRGFKARMIQSEMQIARIAGVPYVPVQHKLVRPKSLMDTL------------KTKGMFKK 274

  Fly   356 AFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFF--MPLLIMD--- 415
            .|  ..|.:      |.:..:..:...|:...|.||.|.|..:..::.:   |  |.||.:|
 Worm   275 LF--ILWTM------WFIIAICGFANDLSSGTLAGDLYLNQLFFGILLV---FSKMLLLFVDTYF 328

  Fly   416 -RFGRRYSLCGLMLASGLCC--IGTIFTGAD-QPVLQLVLFLVGKLTITASFQVLYFFASEIYPT 476
             .|.||....|..:.: |||  |.|.|...| ..:..|:::|:|...|..::...|..|.|:..|
 Worm   329 TNFKRRTLHQGSQIGT-LCCFIILTTFMSMDYHGIGVLIVYLIGTTFIEYTWDACYLCAIELMET 392

  Fly   477 NLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYAN---APA----MLFAGAAIVSGLLTLFF-PETT 533
            ..|.|....||::.|.|.:|||...     |||   :||    ::..|:|.:  |::.|| ||:.
 Worm   393 PSRASATGSCSLIARIGMILAPFLT-----YANTWWSPAVNVTVIVLGSANL--LISYFFLPESK 450

  Fly   534 NVVL 537
            .|.|
 Worm   451 GVNL 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	105/429 (24%)
T12B3.2	NP_501177.1	2A0119	<64..456	CDD:273328	108/431 (25%)