Protein Alignment SLC22A and F45E10.2

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001022174.1
• Gene: F45E10.2 / 185801
• WormBaseID: WBGene00009729
• Length: 538
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 142/548 - (25%)
• Similarity: 240/548 - (43%)
• Gaps: 100/548 - (18%)

  Fly    22 SEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYY 86
            ::.:.|::|.:.||.|||||.|.|:|||:|:.|.:|..:::.|..:.....|:
 Worm    63 NDKIKLESIFEGLGSFGRFQQIQFILICIPIAFVSMHVMSWTFVVSPARKICN------------ 115

  Fly    87 EPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISND 151
                    ..|...:|.|.....|...:|.                               :..|
 Worm   116 --------ETNETRIDGCEELAYSASDRWE-------------------------------MDGD 141

  Fly   152 FGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWF 216
            .|      |..:.|..:..:||..|....|.:||:.||...:....:|..|..::...:|::..:
 Worm   142 NG------WIRATVQAVYFIGQMIGSFTCGVMADKIGRKKVLFWCLVLQVVCALLLIVAPTWWIY 200

  Fly   217 LVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRI 281
            .:.:.....|...:|....|:||||||.|.|.....:..||..:|.||||:.|....|:|:|...
 Worm   201 AILKAGTGFTQPGIYGVAVVLGIELVGKKYRSFIAVIANVFGVIGGVLLAVMAYFIVDYRLLHAS 265

  Fly   282 TYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKL-----VLANRD 341
            ...||||.:.|:|::.||.|||:||.|.:.|..:|...|:.||:.:|::..:|:     |.|.:.
 Worm   266 IAIPSLIFITYYWMIHESARWLVSQEKYDDANVVLCATANWNKKTIPKNWAEKIEKKMDVTATKK 330

  Fly   342 KLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPG 406
            |   .|...|.:....:..|..||| .:.|.|..::||||::...:..|..:..|....|:|:|.
 Worm   331 K---DSFGVFDLIRTPQMRKRTIAN-FVMWPVTTMMYYGLTMRSDVGGGSLFVTFVTSQLMELPA 391

  Fly   407 FFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQP-VLQLVLFLVGKLTITASFQVLYFFA 470
            ..:..|::||.|||....|.:..:|:..:.:..|....| ...:::.:|.|..::.::.|:|.:.
 Worm   392 VIIVALLIDRLGRRIMYSGAIFTAGMLLLASWLTHDLIPSQYAVIMLMVAKGAVSVAYTVMYTYT 456

  Fly   471 SEIYPTNLRNSLLSFCSMMGRFGS------------------MLAPQTPLLAKYYANAPAMLFAG 517
            ||::||.:||:.:..||.:.|||:                  |:.|.|            :|...
 Worm   457 SELFPTVIRNTAVGCCSTIARFGAISASFIAFFLVDRFGRIVMIIPFT------------ILALC 509

  Fly   518 AAIVSGLLTLFFPETTNVVLPTTVQEAD 545
            |:|||..:   .|||.|..||.::.|.:
 Worm   510 ASIVSWTM---LPETVNQQLPDSISEVE 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	111/417 (27%)
F45E10.2	NP_001022174.1	MFS_SLC22	121..518	CDD:340875	115/452 (25%)