DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and F32H5.4

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001370023.1	Gene:	F32H5.4 / 185216	WormBaseID:	WBGene00009350	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	138/566 - (24%)
Similarity:	236/566 - (41%)	Gaps:	87/566 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEAPPADPAVEVAPPAKDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAAT 68
            |..|..:..|::.||   .|:.|||..:| ||::           |..::|   ||...:.:.|
Worm     8 SFGPNQENEVQLLPP---KEEKTLDNFMK-LGKY-----------CWLILF---FSEFMLLSGA- 53

  Fly    69 VTHRCSVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEA 133
                         |:..|..:.. :.||    |.||      |.|. ....|||.:.....|...
Worm    54 -------------GNTLYMMYAG-AYPK----LVSC------EGPD-VFIKDICKSSFDFHNPPN 93

  Fly   134 CAHNEFVFRDDEVTISNDFGIFC-DDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGG 197
            |.   ...:.|..:|:.|:|.|| :..|..:.: ::..:|...|....|.|||||||...:::..
Worm    94 CT---ITSKYDFYSINVDYGHFCGEGAWVKTSI-SVQMVGVLIGSVTSGAVADRYGRLKVLSVCF 154

  Fly   198 ILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGE 262
            .:.:.|.::.:|:....:|.:...:.::....|.||..|..:|.|..:.|....::|:  :|...
Worm   155 FMVSSLSILNTFAKDLIYFTIIRTILSIFKGGLLSTYGVYKMEHVPRQHRFWIATMIS--WAPNY 217

  Fly   263 VLLAMSAKAFHDWRILLRITYGPSLILLA-----YFWILPESVRWLLSQGKEERAKNILRRAAHV 322
            ::|:..|...|||     |||..::..|:     .|..:.||.|||:..|:.|.|:.:|:....|
Worm   218 MILSFVAYLCHDW-----ITYQYAIFALSMPGAVVFLFVKESPRWLIQAGRIEEARQVLKHIMEV 277

  Fly   323 --NKRELPESVLDKLVLANRDKLQQSSESR--FPIREAFKNFKWRIANCSLCWI---VHVLVYYG 380
              |..:...:.:::::...:.:.::..:.|  :..|..|.| |:..:...:.|:   ......||
Worm   278 DGNTSDHSWNEIEEMLQTEKKRQEERIKKRKNYDFRHLFWN-KYMASVTMILWLGMFSTSFTNYG 341

  Fly   381 LSLNVVLLDGDKYNNFAYI-ALVEIPGFFMPL--LIMDRFGRRYSLCGLMLASGL---CCIGTIF 439
            ...|:..|.|..|.|...: :|..:...|..|  |...:.||::    :.|.|.|   .|:.:||
Worm   342 FVFNIEKLSGSLYINALLMGSLRWVLNIFFGLADLKFAKLGRKH----IHLISKLTITICVFSIF 402

  Fly   440 T------GADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP 498
            .      ..|..::..|..|:...|.:..|........|.|||.:|||.:||.|...|.|::|.|
Worm   403 VTYYFEYEEDYSLIIRVATLLASATASQVFITKSMVLMEFYPTVIRNSAVSFKSSASRIGTILGP 467

  Fly   499 QTPLLAKYYANAPAMLFAGAAIVSGL-LTLFFPETTNVVLPTTVQE 543
            |..:|.. |.:.|..:..|..:...: ..|..|||....||.|:.|
Worm   468 QLFILCP-YKSLPYAILTGFCLFDAIAFQLRLPETKGKPLPETMPE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	125/530 (24%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	99/409 (24%)
F32H5.4	NP_001370023.1	2A0119	<104..509	CDD:273328	104/418 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D762280at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020