Protein Alignment SLC22A and C46C2.2

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_501604.2
• Gene: C46C2.2 / 177744
• WormBaseID: WBGene00008110
• Length: 520
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 136/589 - (23%)
• Similarity: 231/589 - (39%)
• Gaps: 155/589 - (26%)

  Fly    33 HLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN------ 91
            |:...|.:::.:.:||...|..  .||:..:|                |....|.|.||
 Worm     2 HIIPPGIYRVDVLILISYQMCH--FFSIQQLF----------------PIFLNYTPKTNCIQTAQ 48

  Fly    92 ----WSIPKNGKDLDSCNRYTNSELPQWNHSVDICS-------ADHFTKNKEACAHNEFVFRDDE 145
                :.:||:     .|..| |...|      ::|:       :|..|:.    :|:.:
 Worm    49 GKVCYDVPKS-----KCLEY-NENFP------NLCANLTGTALSDCHTEK----SHSYY------ 91

  Fly   146 VTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV-IRSF 209
            .:.:.:|.|:|...||......:..:|...|..|.|:|||:.||..:.    ||..::|: ..|.
 Worm    92 SSAAMEFEIYCRPGWKDFRPAFVQYVGVLIGNIILGYVADQIGRKKTF----ILSMLIGIPSLSL 152

  Fly   210 SPSYGWFLVFEFLDNMTSSTLYSTCFVIG----IELVGPKRRVLACSVITVF--YAVGEVLLAMS 268
            |.::.....|.....:|...:..| .::|    .|||.|.:|.    .:..|  :|...::|.:.
 Worm   153 SATFNSIAAFYIFRALTGIGIAGT-MIVGWAYFSELVSPHQRF----KLRTFSNWANARIMLTLV 212

  Fly   269 AKAFHDWRILLRITYGPSLILLA-YFWILPESVRWLLSQGKEERAKNILRRAAHVNKREL----- 327
            |....:||:...::...|||.|| .::|||||..||..:|:.|.|:...:|.|.:...|.
 Worm   213 ALFTGEWRLSSHVSAVISLITLAIVYFILPESHIWLRKKGRYEEAEVSRKRIADLAGIEFVPMPP 277

  Fly   328 PESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLD--- 389
            ||...|.:          ..|....|...|.:.:.| .|..:.|    |:::...:...|.|
 Worm   278 PEKAADNV----------EPEKAVNICTVFADPQLR-KNILILW----LMWFVTGMTAYLTDLCG 327

  Fly   390 GDKYNNF--------AYIALVE-IPGF---FMPLLIMDRFGRRY-SLCGLMLASGL--CCIGTIF 439
            ||...||        ..:::|. |.||   ::|.:     |||: .||...||...  |.|..:|
 Worm   328 GDMTKNFWVGQFLSGILLSVVRIIMGFADGYLPWM-----GRRFVLLCSQSLAIVFFGCVIAFLF 387

  Fly   440 TGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLA 504
            .|.........::|...:..:..::..|..|||:.||::|.:..:.||::|||.::
 Worm   388 AGEKGQWYYTAVYLASFVFTSIVWEPCYLCASELMPTDVRATSTASCSIVGRFANI--------- 443

  Fly   505 KYYANAPAMLFAGAAIVSGLLTLFFPET---------TNVVLPTTVQEADAIGVKKQSKSKDLDL 560
                        ||:::|||.|::.|..         ||||.        |....:::|:..||.
 Worm   444 ------------GASMLSGLKTVYEPGVHMISISLGLTNVVA--------AYFFLQETKNCSLDK 488

  Fly   561 VVTA 564
            ..|:
 Worm   489 AGTS 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	130/561 (23%)
		MFS	146..530	CDD:119392	103/414 (25%)
C46C2.2	NP_501604.2	2A0119	58..486	CDD:273328	118/507 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162847
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840