DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and oat-1

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_501442.2	Gene:	oat-1 / 177649	WormBaseID:	WBGene00003837	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	134/560 - (23%)
Similarity:	220/560 - (39%)	Gaps:	108/560 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KDSEDVTLDAILKHLGQFG--------RFQLIIFLLICLPMMFHAMFSV-TYVFTAATVTHRCSV 75
            ||.||..:..:|....:|.        |:..::.|::.....|.|:.|| ..||..|..|    |
Worm    17 KDVEDQKVLEVLTSHSKFKSLDDLVELRWYCMLVLIMAEITAFTALASVMVMVFAGANPT----V 77

  Fly    76 EECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAH-NEF 139
            ..||                                    |..|:.|...:..||:..|.. .|:
Worm    78 VGCD------------------------------------NTVVNGCHEYYSLKNRSGCTPVLEY 106

  Fly   140 VFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLG 204
            .|...:|    :|...|||..|:....||...|...|..|.|.|:|.:||..::.:..|..|:..
Worm   107 QFESVQV----EFNYICDDAKKVKNTITIQTFGVLVGAAIFGQVSDNFGRRKALIISCIGNAIFN 167

  Fly   205 VIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSA 269
            :|.|:|||..:|:::..:..:.:..|.....|..:|.:....|:...:.||  ::...::....|
Worm   168 LISSYSPSLFYFMLWRTVSGIFAGGLTVVQMVYMVENIPRHHRMWIQNSIT--WSPNLIIFPYIA 230

  Fly   270 KAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNIL---RRAAHVNKRELPESV 331
            ....:||.|..:....|::......:|.||.|||:.:||.|.|:.:|   |:...:...:. |..
Worm   231 YLAQNWRTLSVVISATSVLSFLALMLLEESPRWLVQKGKLEEARRLLIKIRKTDGLYTSDF-EKD 294

  Fly   332 LDKL--VLANRDKLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVL----VYYGLSLNVVLLDG 390
            ||::  :.|.:..:......::.....|  ..|::...::.:||.::    :.|.|..|:..|.|
Worm   295 LDEVLKIEAEKQVISSKKSKKYTFIHLF--CTWKMIAQTMTFIVGIICTNFIVYALLYNMEKLSG 357

  Fly   391 DKYNNFAYIA--------LVEIPGFFMPLLIMDRFGRR--------YSLCGLMLASGLCCIG--- 436
            ..|.|.|.|.        :|.|..:.:|.     ||||        ::|..|.:.:|...||
Worm   358 SLYWNSAIIGAARWVVNIVVSIADYQLPW-----FGRRLINHISMIFTLASLAIVAGYVYIGNGG 417

  Fly   437 -TIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQT 500
             .:..|.     .:.|.:..:|     |...|...:|:|||.:||..:|..|.|.|.|.|.:||.
Worm   418 YVVAIGT-----TVALAMCSQL-----FIAKYLMVNELYPTAVRNLAVSAVSTMSRVGGMFSPQL 472

  Fly   501 PLLAKYYANAPAMLFAGAAIVSGLLTLF---FPETTNVVL 537
            ..|:......|..:..|..:|.  |.||   .|||..|.|
Worm   473 FYLSDIAEWIPYAVLVGFQLVD--LVLFCITIPETKGVHL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	129/545 (24%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	102/415 (25%)
oat-1	NP_501442.2	2A0119	36..513	CDD:273328	128/541 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D762280at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960