Protein Alignment SLC22A and F23F12.3

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_498433.3
• Gene: F23F12.3 / 175926
• WormBaseID: WBGene00017751
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 536
• Identity: 124/536 - (23%)
• Similarity: 220/536 - (41%)
• Gaps: 100/536 - (18%)

  Fly    39 RFQLIIFLLICLPMMF--HAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNWSIPKNGKDL 101
            ||.::.|.|....:.:  ..:|.:.|.|....        .|:.||.|:.:|....|      .:
 Worm     8 RFHILCFFLWQFGLFYACQLIFPIFYNFHPGL--------SCEDPGFNFSKPKCKLS------KV 58

  Fly   102 DSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISNDFGIFC-----DDEWK 161
            :.|...|.:           ||..|.   :.|..|          ::..||.:||     |..|
 Worm    59 EICTELTAN-----------CSKWHI---EPAPFH----------SMVQDFKMFCGTKAYDSAW- 98

  Fly   162 LSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMT 226
               :.||..:|...|..:.|.:.|.:||.....:|..:|.:.||...|:||:..|.|..|:...:
 Worm    99 ---IATIQFIGALVGALVYGHLGDHFGRKPVSFVGISIGIIFGVASGFAPSWEVFAVLLFICGTS 160

  Fly   227 SSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAF--HDWRILLRITYGPSLIL 289
            .:.:....:...:|.:.|::||.    :..|:..|...|..:...|  ..||.....|...:|.:
 Worm   161 VACIMIVFYAYILEFIEPEQRVF----LRTFFNWGYARLVFTLVCFICGYWRSAAIATSLLALPI 221

  Fly   290 LAYFWILPESVRWLLSQGK----EERAKNI--LRRAAHVNKRELPESVLDKLVLANRDKLQQSSE 348
            |.....||||.:|..::.:    :|..|.|  |...::|.:.:           ...:|:::...
 Worm   222 LPVLLWLPESPKWYATKNRFQEMKEAEKKISWLSGISYVERED-----------RRTEKIEEKDT 275

  Fly   349 SRFPIREAFKNFKWRIANCSL----CWIVHVLVYYGLSLNVVLLDGDKY-NNF---AYIALVEIP 405
            ..:.||:.|.:  |.||..::    .|....:..:|..||...|.|:.| :.|   |.|||.::.
 Worm   276 KVYTIRDLFSS--WPIAYSTIVVGSLWFSTSVSSFGADLNSGNLAGNFYLSQFVQAAAIALSKLS 338

  Fly   406 GFFMPLLIMDRFGRR--YSLCGLMLASGLCCIGTIFTGADQP-----------VLQLVLFLVGKL 457
            .|.:.|.| ..|.|:  :.:..:::   :.|..||......|           :..:::.::|..
 Worm   339 IFLLDLFI-PSFNRQRLHQVPQIIM---IACYTTIMALMISPDSDCSSQGSRNLAIIIINIIGTS 399

  Fly   458 TITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVS 522
            .|..::...|..|:||:||.:|...:..||::.|.|::||||...|::.|...|.::.....|:|
 Worm   400 FIELTWDACYLVAAEIFPTRIRTIGIGTCSLLARIGALLAPQMAYLSEIYPPIPYIIVCSIGIIS 464

  Fly   523 GLLTLFF-PETTNVVL 537
            .|::.|| |:|..|.|
 Worm   465 LLISCFFLPDTKGVDL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	124/536 (23%)
		MFS	146..530	CDD:119392	100/418 (24%)
F23F12.3	NP_498433.3	Sugar_tr	76..485	CDD:278511	106/440 (24%)
		MFS	97..>229	CDD:119392	32/139 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D762280at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850