Protein Alignment SLC22A and oct-1

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_492617.4
• Gene: oct-1 / 172841
• WormBaseID: WBGene00003842
• Length: 585
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 153/562 - (27%)
• Similarity: 265/562 - (47%)
• Gaps: 35/562 - (6%)

  Fly     9 ADPAVEVAPPAKDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYV-FTAATVTHR 72
            |:.:.|:...|....|  .|.:|:.:|.:|.:|::.|.:||||....:.||...: |......|.
 Worm    10 AEISQEILMSATKPPD--FDFVLEQVGNYGTYQIVFFFIICLPTSLPSAFSAFNIPFVVGNPPHT 72

  Fly    73 CSVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKN------K 131
            |.:.|    |..|..|.|      |...:.||.:|..:::..: .:......|.::..      :
 Worm    73 CHIPE----GKEYLRPLT------NDTQILSCKQYNETQINVF-RAFTSAPVDTYSDRISLVPCQ 126

  Fly   132 EACAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYG--RSFSIA 194
            ....::...:.|..||   :|.:.||.:..:.:..|...:|.|.|..:.|:|||::|  |||.:.
 Worm   127 NGWDYDNSTYLDSLVT---EFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVI 188

  Fly   195 LGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYA 259
            |..::  |.|...||:.....|::..|...:....|:...|:|.:|.:|...|:.:..:.::|:.
 Worm   189 LTVLI--VCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFG 251

  Fly   260 VGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNK 324
            ....||.:.|.....||.|......|....:.|::.||||.||.:|.||...||..|::.|.:|.
 Worm   252 AAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIAKMNG 316

  Fly   325 RELPESVLDKLV--LANRDKLQQSSESR--FPIREAFK--NFKWRIANCSLCWIVHVLVYYGLSL 383
            :...:  :|:||  :.|.....:..|::  ..:.:.||  |.:.:....:..|:::.::|.||:|
 Worm   317 KSNVD--VDELVDSMKNHQNAAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTL 379

  Fly   384 NVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQ 448
            ||..|..|.|.:|.....||:||:|:...::...|||::|...|:..|:.|:..:|.....|.|.
 Worm   380 NVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLV 444

  Fly   449 LVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAM 513
            .....:||..:.:.|.|:|.||.|:|||.:|...:...||:...|.:|||....|.|.....|.:
 Worm   445 ASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLL 509

  Fly   514 LFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKS 555
            :....|:.:|:||.|.|||....||.|:::|:..|.|.:..|
 Worm   510 IMGLMALSAGILTFFLPETLGAPLPMTIEDAENFGKKPEPDS 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	142/519 (27%)
		MFS	146..530	CDD:119392	113/391 (29%)
oct-1	NP_492617.4	2A0119	34..536	CDD:273328	142/519 (27%)
		MFS	134..526	CDD:119392	114/398 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920